Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, Italy.
Nutrients. 2020 Sep 10;12(9):2751. doi: 10.3390/nu12092751.
Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (ω-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the ω-6PUFAs. Both ω-3 and ω-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food-related disorders. In this review, we present ω-3 and ω-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of ω-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.
最近，人们发现食物中的营养生物活性化合物具有预防慢性疾病（如癌症、炎症、心血管和代谢疾病）的潜在健康益处。饮食中的ω-3 多不饱和脂肪酸（ω-3PUFAs），包括α-亚麻酸、二十二碳五烯酸和二十碳五烯酸，最具吸引力。它们可从全球常用食品中获得，或作为商业食品补充剂的成分。这些脂肪酸具有抗炎和降甘油三酯作用，而其饮食对应物 ω-6PUFAs 则具有促炎特性。ω-3 和 ω-6PUFAs 都有助于产生脂类介质，如内源性大麻素，它们在控制食物摄入、能量感知和与食物相关的疾病中起着重要作用。在这篇综述中，我们介绍了 ω-3 和 ω-6PUFAs 及其衍生物内源性大麻素；讨论了 ω-3PUFAs 的抗肥胖作用；它们在炎症和结直肠癌发展中的作用；以及它们的作用如何具有预防和治疗的双重作用。
Zotero 插件
