患有结核性脑膜炎和新冠病毒合并感染并伴有广泛脑静脉窦血栓形成的儿童。
Child with tuberculous meningitis and COVID-19 coinfection complicated by extensive cerebral sinus venous thrombosis.
作者信息
Essajee Farida, Solomons Regan, Goussard Pierre, Van Toorn Ronald
机构信息
Department of Pediatrics and Child Health, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South Africa.
Department of Pediatrics and Child Health, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South Africa
出版信息
BMJ Case Rep. 2020 Sep 14;13(9):e238597. doi: 10.1136/bcr-2020-238597.
We herein report a case of a child with tuberculous meningitis and COVID-19 coinfection complicated by hydrocephalus, arterial ischaemic stroke and extensive cerebral sinus venous thrombosis. Both conditions induce a proinflammatory cytokine drive resulting, among others, in a prothrombotic state. The disruption of the coagulation system in this case was supported by elevated D-dimers, fibrinogen and ferritin levels, consistent with thrombotic complications reported in some adult patients infected with COVID-19. The child also exhibited prolonged viral shedding that suggests severe disease.
我们在此报告一例患有结核性脑膜炎和新冠病毒感染合并症的儿童病例，该病例并发脑积水、动脉缺血性中风和广泛的脑静脉窦血栓形成。这两种病症都会引发促炎细胞因子驱动，进而导致多种情况，包括血栓前状态。该病例中凝血系统的紊乱表现为D-二聚体、纤维蛋白原和铁蛋白水平升高，这与一些感染新冠病毒的成年患者所报告的血栓并发症一致。该儿童还出现了病毒长期脱落的情况，这表明病情严重。
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