Biology Department, University of Puerto Rico, Puerto Rico.
Int J Dev Biol. 2021;65(4-5-6):427-437. doi: 10.1387/ijdb.200227dq.
Regeneration of lost or injured organs is an intriguing process in which numerous cellular events take place to form the new structure. Studies of this process during reconstitution of the intestine have been performed in echinoderms, particularly in holothurians. Many cellular events triggered during regeneration have been described using the sea cucumber as a research model. More recent experiments have targeted the molecular mechanisms behind the process, a task that has been facilitated by the new sequencing technologies now available. In this review, we present studies involving cellular processes and the genes that have been identified to be associated with the early events of gut regeneration. We also present ongoing efforts to perform functional studies necessary to establish the role(s) of the identified genes. A synopsis of the studies is given with the course of the regenerative process established so far.
器官的再生是一个有趣的过程，在此过程中会发生许多细胞事件来形成新的结构。人们在棘皮动物，尤其是海参中研究了肠道重建过程中的这一过程。使用海参作为研究模型，已经描述了许多在再生过程中触发的细胞事件。最近的实验针对的是该过程背后的分子机制，这一任务得益于现在可用的新型测序技术。在这篇综述中，我们介绍了涉及细胞过程和已确定与肠道再生早期事件相关的基因的研究。我们还介绍了正在进行的功能研究，以确定已鉴定基因的作用。概述了迄今为止建立的再生过程的研究进展。
