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发展中国家食管闭锁手术新生儿的第一年随访:仅仅手术是不够的!

First-Year follow-up of Newborns Operated for Esophageal Atresia in a Developing Country: Just Operating is not Enough!

作者信息

Dey Santosh, Jain Vishesh, Anand Sachit, Agarwala Sandeep, Dhua Anjan, Srinivas M, Bhatnagar Veereshwar

机构信息

Department of Pediatric Surgery, Command Hospital, Pune, Maharashtra, India.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Indian Assoc Pediatr Surg. 2020 Jul-Aug;25(4):206-212. doi: 10.4103/jiaps.JIAPS_88_19. Epub 2020 Jun 24.

Abstract

PURPOSE

To identify complications, their incidence and risk factors for their occurrence in patients of esophageal atresia (EA) in the 1 year after discharge following surgery.

MATERIALS AND METHODS

Cases of EA discharged after surgical intervention in the period of July 2011-July 2013 were considered a cohort. All data regarding demographics, investigations, surgical procedure, outcome, and follow-up were recorded.

RESULTS

Seventy-six such patients were discharged in the study period, six of whom were lost to follow-up, and hence, seventy patients were included in the study. Of these 70, 48 (69%) had esophageal continuity restored (46 EA + tracheoesophageal fistula [TEF]; 2 pure EA), while 22 (31%) had been diverted (3 pure EA; 8 EA + TEF following major leak; 11 long gap EA + TEF). Risk of developing any complication (except death) was 48/70 (68%; 95% confidence interval [CI] = 57.4-79.7). Twenty-six of 48 patients with esophageal continuity restored, demonstrated narrowing on contrast study (54%; 95% CI = 39.5-68.7) but only 18 of these 48 (37.5%) had dysphagia. Thirty-one of seventy had an episode of lower respiratory tract infection (LRTI) (44.2%; 95% CI = 32.3%-56.2%). Poor weight gain was observed in 27/70 (37%), and this was significantly common in diverted patients (63% vs. 25%; = 0.009). Twenty-one of total 70 (30%) patients died within the 1 year following discharge.

CONCLUSIONS

Sixty-eight percent of cases developed some complication, while 30% succumbed within the 1 year of life following discharge. The common complications were stricture, LRTI, and poor weight gain. All of these were common in diverted patients.

摘要

目的

确定食管闭锁(EA)患者术后出院1年内并发症的发生情况、发生率及其危险因素。

材料与方法

将2011年7月至2013年7月期间接受手术干预后出院的EA病例作为一个队列。记录所有关于人口统计学、检查、手术过程、结局和随访的数据。

结果

在研究期间,76例此类患者出院,其中6例失访,因此70例患者纳入研究。在这70例患者中,48例(69%)食管连续性得以恢复(46例EA合并气管食管瘘[TEF];2例单纯EA),而22例(31%)进行了转流手术(3例单纯EA;8例EA合并TEF且发生严重渗漏;11例长节段EA合并TEF)。发生任何并发症(死亡除外)的风险为48/70(68%;95%置信区间[CI]=57.4 - 79.7)。48例食管连续性恢复的患者中,26例在造影检查时显示狭窄(54%;95%CI = 39.5 - 68.7),但这48例中只有18例(37.5%)有吞咽困难。70例中有31例发生下呼吸道感染(LRTI)(44.2%;95%CI = 32.3% - 56.2%)。27/70(37%)患者体重增加不佳在转流手术患者中显著常见(63%对25%;P = 0.009)。7总0例患者中有21例(30%)在出院后1年内死亡。

结论

68%的病例发生了某种并发症,而30%在出院后1年内死亡。常见并发症为狭窄、LRTI和体重增加不佳。所有这些在转流手术患者中都很常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c055/7478287/c90ba7f76aa6/JIAPS-25-206-g001.jpg

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