台湾北部视网膜血管炎的临床和流行病学特征。
Clinical and Epidemiological Profiles of Retinal Vasculitis in Northern Taiwan.
机构信息
Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
出版信息
Ocul Immunol Inflamm. 2022 Feb 17;30(2):310-317. doi: 10.1080/09273948.2020.1811352. Epub 2020 Sep 17.
PURPOSE
To investigate the epidemiological and clinical profiles in retinal vasculitis in an Asian cohort.
METHODS
A 5-year retrospective study of 487 uveitis patients in a tertiary referral center at northern Taiwan.
RESULTS
Overall, 18.5% of the cases were associated with retinal vasculitis (RV). Sarcoidosis and cytomegalovirus retinitis were two leading diagnoses. Cases with RV were younger (mean: 39.7 years), less unilateral (50%), and had more chorioretinal involvement (95.5%). Definite diagnosis was reached in 86.7% of RV cases, of which 38.5% had infectious uveitis. While sole arteritis was presented in 8.9% of cases, 63.3% showed phlebitis, and 27.8% involved both. Three distinctive patterns were associated with a higher likelihood of infection: nodular sheathing, continuous perivascular sheathing (OR 4.79), and continuous fluorescein leakage (OR 4.11).
CONCLUSION
The presence of RV, especially arteritis, is highly suggestive of identifiable etiology. Distinctive clinical patterns help differentiation of infectious versus noninfectious causes.
目的
调查亚洲队列中视网膜血管炎的流行病学和临床特征。
方法
对台湾北部一家三级转诊中心的 487 名葡萄膜炎患者进行了为期 5 年的回顾性研究。
结果
总体而言，18.5%的病例与视网膜血管炎（RV）有关。结节病和巨细胞病毒视网膜炎是两个主要的诊断。RV 患者更年轻（平均年龄：39.7 岁），单侧性（50%）更少，脉络膜视网膜受累更多（95.5%）。86.7%的 RV 病例得到明确诊断，其中 38.5%为感染性葡萄膜炎。虽然 8.9%的病例仅表现为动脉炎，但 63.3%表现为静脉炎，27.8%两者均有。三种不同的模式与更高的感染可能性相关：结节性鞘，连续血管周围鞘（OR 4.79）和连续荧光素渗漏（OR 4.11）。
结论
RV 的存在，特别是动脉炎，高度提示可识别的病因。独特的临床模式有助于区分感染性和非感染性病因。
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