Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.
Department of Leukemia and.
Blood Adv. 2020 Sep 22;4(18):4508-4511. doi: 10.1182/bloodadvances.2020002454.
An incidental histologic diagnosis of DLBCL was identified during temporary interruption of ibrutinib treatment in patients with CLL. In contrast to an aggressive clinical course typical of Richter transformation, these patients responded to reinitiation of ibrutinib alone.
在慢性淋巴细胞白血病(CLL)患者中断伊布替尼治疗期间偶然发现弥漫性大 B 细胞淋巴瘤(DLBCL)的组织学诊断。与典型 Richter 转化的侵袭性临床病程相反,这些患者对重新开始单独使用伊布替尼有反应。