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异物气道梗阻的解除:干预措施的系统评价

Removal of foreign body airway obstruction: A systematic review of interventions.

作者信息

Couper Keith, Abu Hassan Aysha, Ohri Vrinda, Patterson Emma, Tang Ho Tsun, Bingham Robert, Olasveengen Theresa, Perkins Gavin D

机构信息

Warwick Medical School, University of Warwick, Coventry, UK; Critical Care Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Warwick Medical School, University of Warwick, Coventry, UK.

出版信息

Resuscitation. 2020 Nov;156:174-181. doi: 10.1016/j.resuscitation.2020.09.007. Epub 2020 Sep 16.

Abstract

OBJECTIVE

To summarise in a systematic review the effectiveness of interventions to treat foreign body airway obstructions (FBAO).

METHODS

We searched MEDLINE, EMBASE, and the Cochrane library from inception on 30th September 2019 for studies that described the effectiveness of interventions to treat FBAO in adults and children. We included randomised controlled trials, observational studies and case series (≥5 cases) that described evidence of benefit. For evidence of harm/complications, we included case reports. Two reviewers independently assessed study eligibility, extracted study data, and assessed risk of bias. Data are summarised in a narrative synthesis. The GRADE system is used to assess evidence certainty.

RESULTS

We included 69 publications, comprising three cross-sectional studies (557 patients); eight case series (755 patients), and 59 were case reports (64 patients). One paper was included as a case series and cross-sectional study. For all interventions and associated outcomes, evidence certainty was very low. Early removal of FBAO by bystanders was associated with improved neurological survival (odds ratio 6.0, 95% confidence interval 1.5 to 23.4). Identified evidence showed that key interventions (back blows, abdominal thrusts, chest thrusts/compressions, Magill forceps, manual removal of obstructions from the mouth, suction-based airway clearance devices) are effective in relieving FBAO. We identified reports of harm in relation to back blows, abdominal thrusts, chest thrusts/compressions, and blind finger sweeps.

CONCLUSIONS

Key interventions successfully relieve FBAO, but may be associated with important harms. Guidelines for FBAO management should balance the benefits and harms of interventions.

摘要

目的

通过系统评价总结治疗异物气道梗阻(FBAO)干预措施的有效性。

方法

我们检索了MEDLINE、EMBASE和Cochrane图书馆,检索时间从建库起至2019年9月30日,以查找描述治疗成人和儿童FBAO干预措施有效性的研究。我们纳入了描述有益证据的随机对照试验、观察性研究和病例系列(≥5例)。对于危害/并发症的证据,我们纳入了病例报告。两名 reviewers 独立评估研究的合格性,提取研究数据,并评估偏倚风险。数据以叙述性综合的方式进行总结。采用GRADE系统评估证据的确定性。

结果

我们纳入了69篇出版物,包括三项横断面研究(557例患者);八项病例系列(755例患者),59篇为病例报告(64例患者)。一篇论文同时作为病例系列和横断面研究纳入。对于所有干预措施及其相关结局,证据确定性非常低。旁观者早期清除FBAO与改善神经功能存活相关(比值比6.0,95%置信区间1.5至23.4)。已确定的证据表明,关键干预措施(背部叩击、腹部冲击、胸部冲击/按压、麦吉尔钳、手动清除口腔内异物、基于吸引的气道清理装置)可有效缓解FBAO。我们发现了与背部叩击、腹部冲击、胸部冲击/按压和盲目手指探查相关的危害报告。

结论

关键干预措施可成功缓解FBAO,但可能伴有重要危害。FBAO管理指南应权衡干预措施的利弊。

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