甲状腺疾病与 SARS-CoV-2 感染：从病理生理学机制到患者管理。
Thyroid disorders and SARS-CoV-2 infection: From pathophysiological mechanism to patient management.
机构信息
Service d'endocrinologie et maladies métaboliques, pôle cardiovasculaire et métabolique, CHU Larrey, 24, chemin de Pouvourville, TSA 30030, 31059 Toulouse cedex, France.
出版信息
Ann Endocrinol (Paris). 2020 Oct;81(5):507-510. doi: 10.1016/j.ando.2020.09.001. Epub 2020 Sep 18.
Abstract
The World Health Organization (WHO) declared the COVID-19 epidemic to be a global pandemic in March 2020. COVID-19 is an infection caused by SARS-CoV-2, a coronavirus that utilizes the angiotensin-2 converting enzyme to penetrate thyroid and pituitary cells, and may result in a "cytokine storm". Based on the pathophysiological involvement of the pituitary-thyroid axis, the current review discusses the diagnosis of abnormal thyroid function test, and the management of patients presenting with thyrotoxicosis, thyroid-associated orbitopathy and hypothyroidism in the context of SARS-CoV-2 infection.
摘要
世界卫生组织（WHO）于 2020 年 3 月宣布 COVID-19 疫情为全球大流行。COVID-19 是由 SARS-CoV-2 引起的感染，该病毒利用血管紧张素转化酶穿透甲状腺和垂体细胞，可能导致“细胞因子风暴”。基于垂体-甲状腺轴的病理生理学受累，本综述讨论了 SARS-CoV-2 感染背景下异常甲状腺功能试验的诊断以及甲状腺功能亢进、甲状腺相关眼病和甲状腺功能减退患者的管理。
相似文献
1
Thyroid disorders and SARS-CoV-2 infection: From pathophysiological mechanism to patient management.
Ann Endocrinol (Paris). 2020 Oct;81(5):507-510. doi: 10.1016/j.ando.2020.09.001. Epub 2020 Sep 18.
2
May IL-17 have a role in COVID-19 infection?
Med Hypotheses. 2020 Jul;140:109749. doi: 10.1016/j.mehy.2020.109749. Epub 2020 Apr 22.
3
Would ACEIs/ARBs be beneficial for COVID-19 patients without hypertension?
Pharmacol Res. 2020 Sep;159:104959. doi: 10.1016/j.phrs.2020.104959. Epub 2020 Jun 4.
4
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids.
Protein Cell. 2020 Oct;11(10):771-775. doi: 10.1007/s13238-020-00718-6.
5
Thyrotoxicosis in patients with COVID-19: the THYRCOV study.
Eur J Endocrinol. 2020 Oct;183(4):381-387. doi: 10.1530/EJE-20-0335.
6
Purposing Saikosaponins for the treatment of COVID-19.
Med Hypotheses. 2020 Jul;140:109782. doi: 10.1016/j.mehy.2020.109782. Epub 2020 Apr 23.
7
The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries.
J Neurol Sci. 2020 Jul 15;414:116884. doi: 10.1016/j.jns.2020.116884. Epub 2020 May 7.
8
Understanding the renin-angiotensin-aldosterone-SARS-CoV axis: a comprehensive review.
Eur Respir J. 2020 Jul 9;56(1). doi: 10.1183/13993003.00912-2020. Print 2020 Jul.
9
Coronavirus disease 2019 and the cardiovascular system: Impacts and implications.
Indian Heart J. 2020 Jan-Feb;72(1):1-6. doi: 10.1016/j.ihj.2020.03.006. Epub 2020 Apr 9.
10
[Renin-Angiotensin-System (RAS) and COVID-19 - On The Prescription of RAS Blockers].
Pneumologie. 2020 Sep;74(9):611-614. doi: 10.1055/a-1165-6994. Epub 2020 Sep 11.
引用本文的文献
1
The Perfect Storm: Co-occurrence of Agranulocytosis and Thyroid Storm Successfully Managed with Lithium Therapy.
J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251336657. doi: 10.1177/23247096251336657. Epub 2025 Apr 25.
2
Investigation of Potential Targets for Bupleuri Radix in the Treatment of Subacute Thyroiditis.
Int J Endocrinol. 2025 Mar 11;2025:7460422. doi: 10.1155/ije/7460422. eCollection 2025.
3
Long-Term Impacts of COVID-19 on Thyroid Health: Insights From Clinical Studies.
Cureus. 2024 Oct 14;16(10):e71469. doi: 10.7759/cureus.71469. eCollection 2024 Oct.
4
Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches.
Drug Des Devel Ther. 2024 Sep 20;18:4215-4240. doi: 10.2147/DDDT.S475005. eCollection 2024.
5
Mendelian randomization provides causal association between COVID-19 and thyroid cancer: insights from a multi-cancer analysis.
Front Oncol. 2024 Sep 10;14:1419020. doi: 10.3389/fonc.2024.1419020. eCollection 2024.
6
Comparison of treatment outcome between glucocorticoids and non-steroidal anti-inflammatory drugs in subacute thyroiditis patients-a systematic review and meta-analysis.
Front Endocrinol (Lausanne). 2024 Apr 23;15:1384365. doi: 10.3389/fendo.2024.1384365. eCollection 2024.
7
The Influence of Autoimmune Thyroid Diseases on Viral Pneumonia Development, Including COVID-19: A Two-Sample Mendelian Randomization Study.
Pathogens. 2024 Jan 24;13(2):101. doi: 10.3390/pathogens13020101.
8
Development of autoimmune thyroid disease after COVID-19 infection: case report.
Front Med (Lausanne). 2024 Feb 7;11:1303855. doi: 10.3389/fmed.2024.1303855. eCollection 2024.
9
Prognostic role of euthyroid sick syndrome in MIS-C: results from a single-center observational study.
Front Pediatr. 2023 Aug 10;11:1217151. doi: 10.3389/fped.2023.1217151. eCollection 2023.
10
The COVID-19 Pandemic: SARS-CoV-2 Structure, Infection, Transmission, Symptomology, and Variants of Concern.
Adv Exp Med Biol. 2023;1412:3-26. doi: 10.1007/978-3-031-28012-2_1.
本文引用的文献
1
Is Subacute Thyroiditis an Underestimated Manifestation of SARS-CoV-2 Infection? Insights From a Case Series.
J Clin Endocrinol Metab. 2020 Oct 1;105(10). doi: 10.1210/clinem/dgaa537.
2
COVID-19: A review of the proposed pharmacological treatments.
Eur J Pharmacol. 2020 Nov 5;886:173451. doi: 10.1016/j.ejphar.2020.173451. Epub 2020 Aug 6.
3
SARS-CoV-2-related atypical thyroiditis.
Lancet Diabetes Endocrinol. 2020 Sep;8(9):739-741. doi: 10.1016/S2213-8587(20)30266-7. Epub 2020 Jul 30.
4
Thyrotoxicosis in patients with COVID-19: the THYRCOV study.
Eur J Endocrinol. 2020 Oct;183(4):381-387. doi: 10.1530/EJE-20-0335.
5
Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic.
Hormones (Athens). 2021 Mar;20(1):219-221. doi: 10.1007/s42000-020-00230-w. Epub 2020 Jul 16.
6
COVID-19 complicated by Hashimoto's thyroiditis.
Singapore Med J. 2021 May;62(5):265. doi: 10.11622/smedj.2020106. Epub 2020 Jul 16.
7
Endocrine Significance of SARS-CoV-2's Reliance on ACE2.
Endocrinology. 2020 Sep 1;161(9). doi: 10.1210/endocr/bqaa108.
8
Endocrine and metabolic aspects of the COVID-19 pandemic.
Rev Endocr Metab Disord. 2020 Dec;21(4):495-507. doi: 10.1007/s11154-020-09569-2.
9
Thyroid Function Analysis in 50 Patients with COVID-19: A Retrospective Study.
Thyroid. 2021 Jan;31(1):8-11. doi: 10.1089/thy.2020.0363. Epub 2020 Jul 10.
10
Endocrine changes in SARS-CoV-2 patients and lessons from SARS-CoV.
Postgrad Med J. 2020 Jul;96(1137):412-416. doi: 10.1136/postgradmedj-2020-137934. Epub 2020 Jun 11.
Zotero 插件