Wnt 和 Hippo 通路在调节性 T 细胞中的作用：哮喘治疗的新靶点。
Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma.
机构信息
Laboratory of Mucosal Immunology and Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
出版信息
Nat Immunol. 2020 Nov;21(11):1313-1314. doi: 10.1038/s41590-020-0797-z.
Abstract
The activation of the Notch4-Wnt-GDF15 axis in induced Tregs dampens their immunoregulatory function and turns them into Th2 and Th17 cytokine producers, allowing them to maintain ongoing allergic asthma.
摘要
诱导性 Treg 中 Notch4-Wnt-GDF15 轴的激活抑制了其免疫调节功能，并将其转化为 Th2 和 Th17 细胞因子产生细胞，使它们能够维持持续性过敏性哮喘。
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