Institute for Health and Sport (iHeS), Victoria University, Melbourne 8001, Australia.
Dept. Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Int J Mol Sci. 2020 Sep 22;21(18):6948. doi: 10.3390/ijms21186948.
As a major site of glucose uptake following a meal, skeletal muscle has an important role in whole-body glucose metabolism. Evidence in humans and animal models of insulin resistance and type 2 diabetes suggests that alterations in mitochondrial characteristics accompany the development of skeletal muscle insulin resistance. However, it is unclear whether changes in mitochondrial content, respiratory function, or substrate oxidation are central to the development of insulin resistance or occur in response to insulin resistance. Thus, this review will aim to evaluate the apparent conflicting information placing mitochondria as a key organelle in the development of insulin resistance in skeletal muscle.
作为餐后葡萄糖摄取的主要部位，骨骼肌在全身葡萄糖代谢中起着重要作用。胰岛素抵抗和 2 型糖尿病的人类和动物模型中的证据表明，线粒体特征的改变伴随着骨骼肌胰岛素抵抗的发展。然而，线粒体含量、呼吸功能或底物氧化的变化是否是胰岛素抵抗发展的核心，或者是否是对胰岛素抵抗的反应，尚不清楚。因此，本综述旨在评估将线粒体作为骨骼肌胰岛素抵抗发展的关键细胞器的相关矛盾信息。
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