Fan Wenguo, Mai Lijia, Zhu Xiao, Huang Fang, He Hongwen
Department of Anesthesiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Front Cell Neurosci. 2020 Aug 18;14:261. doi: 10.3389/fncel.2020.00261. eCollection 2020.
Perioperative neurocognitive disorder (PND) is a common phenomenon associated with anesthesia and surgery and has been frequently described in the elderly and susceptible individuals. Microglia, which are the brain's major resident immune cells, play critical roles in maintaining neuronal homeostasis and synaptic plasticity. Accumulating evidence suggests microglial dysfunction occurring after anesthesia and surgery might perturb neuronal function and induce PND. This review aims to provide an overview of the involvement of microglia in PND to date. Possible cellular and molecular mechanisms regarding the connection between microglial activation and PND are discussed.
围手术期神经认知障碍（PND）是一种与麻醉和手术相关的常见现象，在老年人和易感个体中经常被描述。小胶质细胞是大脑主要的常驻免疫细胞，在维持神经元稳态和突触可塑性方面发挥着关键作用。越来越多的证据表明，麻醉和手术后发生的小胶质细胞功能障碍可能会扰乱神经元功能并诱发PND。本综述旨在概述迄今为止小胶质细胞在PND中的作用。讨论了小胶质细胞激活与PND之间联系的可能细胞和分子机制。
