一项在前列腺癌幸存者中加入行为咨询以辅助监督体力活动的可行性随机对照试验：前列腺癌幸存者行为改变试验（BOOST）。
A pilot feasibility randomized controlled trial adding behavioral counseling to supervised physical activity in prostate cancer survivors: behavior change in prostate cancer survivors trial (BOOST).
机构信息
Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON, M5S 2W6, Canada.
Department of Psychology, Northeastern University, 619 ISEC (Interdisciplinary Science and Engineering Complex), Boston, MA, 02115, USA.
出版信息
J Behav Med. 2021 Apr;44(2):172-186. doi: 10.1007/s10865-020-00185-8. Epub 2020 Sep 26.
The purpose of this study was to evaluate the feasibility of delivering a supervised physical activity program plus standard exercise counseling (PA + EC) versus a supervised physical activity plus motivationally-enhanced behavioral counseling (PA + BC) in prostate cancer survivors. Secondary outcomes included objectively assessed PA, quality of life, body composition, cardiorespiratory fitness, cognitive functioning, and physical function. Twenty-six prostate cancer survivors were randomized to a 12-week supervised PA program plus standard exercise counseling or a 12-week supervised PA plus behavioral counseling based on the Multi-Process Action Control framework. Feasibility was determined through enrolment rate, measurement completion rate, loss-to-follow-up, adherence to the intervention, adverse events, and program evaluation items assessing burden and satisfaction. Of the 26 prostate cancer survivors enrolled (M = 65.6 ± 6.8), 96% completed the intervention. Measurement completion rates for the study measures were 88.5%. Adherence to the supervised PA sessions was 92% (completed 11/12 supervised PA sessions) and 100% (completed 12/12 supervised PA sessions) in the PA + EC and PA + BC group, respectively. Adherence to the home-based PA sessions was 70% (completed 7/10 home-based sessions) and 90% (completed 9/10 home-based sessions) in the PA + EC and PA + BC group, respectively. Overall, prostate cancer survivors were highly satisfied with the intervention components and found it rewarding, useful for research helping others, and useful for them personally. The patterns in the secondary outcomes were consistent with a positive impact of the intervention, favoring the PA + BC group. Preliminary evidence suggests that adding behavioral counseling to supervised PA in prostate cancer survivors may be feasible and result in better adherence to PA compared to exercise counseling alone, although additional refinement is needed. A combination of supervised and home-based PA may be feasible for behavior change in the self-management of prostate cancer. The study is registered with http://ClinicalTrials.gov (ID NCT03191968).
本研究旨在评估在前列腺癌幸存者中提供监督体力活动计划加标准运动咨询（PA+EC）与监督体力活动加动机增强行为咨询（PA+BC）的可行性。次要结果包括客观评估的体力活动、生活质量、身体成分、心肺健康、认知功能和身体功能。26 名前列腺癌幸存者随机分为 12 周监督体力活动计划加标准运动咨询或 12 周监督体力活动加基于多过程行动控制框架的行为咨询。可行性通过入组率、测量完成率、失访率、对干预的依从性、不良事件以及评估负担和满意度的方案评估项目来确定。在 26 名入组的前列腺癌幸存者中（M=65.6±6.8），96%完成了干预。研究措施的测量完成率为 88.5%。监督体力活动课程的依从性分别为 PA+EC 组 92%（完成 11/12 次监督体力活动课程）和 PA+BC 组 100%（完成 12/12 次监督体力活动课程），家庭为基础的体力活动课程的依从性分别为 PA+EC 组 70%（完成 7/10 次家庭为基础的课程）和 PA+BC 组 90%（完成 9/10 次家庭为基础的课程）。总的来说，前列腺癌幸存者对干预措施非常满意，并认为它有回报，对研究帮助他人有用，对他们个人也有用。次要结果的模式与干预的积极影响一致，对 PA+BC 组有利。初步证据表明，在前列腺癌幸存者中，与单独的运动咨询相比，将行为咨询加入监督体力活动可能是可行的，并且可以提高对体力活动的依从性，尽管还需要进一步改进。监督和家庭为基础的体力活动相结合可能是前列腺癌自我管理中行为改变的可行方法。该研究在 http://ClinicalTrials.gov（注册号 NCT03191968）注册。
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