Miller Michelle A, Cappuccio Francesco P
Division of Health Sciences (Mental Health & Wellbeing), Warwick Medical School, University of Warwick, Coventry, UK.
Division of Health Sciences (Mental Health & Wellbeing), Warwick Medical School, University of Warwick, Coventry, UK; University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK.
Sleep Med Rev. 2021 Feb;55:101382. doi: 10.1016/j.smrv.2020.101382. Epub 2020 Sep 8.
The aims of the study were to review the rapidly emerging COVID-19 literature to determine 1) the relationship between obstructive sleep apnoea (OSA) and adverse COVID-19 outcomes and, 2) potential causal mechanisms 3) what effect COVID-19 has had on OSA diagnosis and 4) what effect COVID-19 has had on treatment and management of OSA during this period. PubMed was systematically searched up to 020620. Studies were included if they had examined the relationship between COVID-19 and OSA. Studies were included that were in English and had the full text available. The findings from this study suggest that many of the risk factors and co-morbidities associated for OSA which include obesity, hypertension and diabetes mellitus are associated with poor COVID-19 outcomes. There are plausible mechanisms by which OSA may independently increase one's risk of morbidity and mortality associated with COVID-19 and data from the newly published CORONADO study suggests that OSA treated patients may be at increased risk of death from COVID-19. It is clear that the pandemic has had a major effect on the treatment management and diagnosis of OSA and moving forward it may be necessary to explore new diagnosis and treatment pathways for these individuals.
本研究的目的是回顾迅速涌现的关于新冠病毒病(COVID-19)的文献,以确定:1)阻塞性睡眠呼吸暂停(OSA)与COVID-19不良结局之间的关系;2)潜在的因果机制;3)COVID-19对OSA诊断有何影响;4)在此期间COVID-19对OSA的治疗和管理有何影响。截至2020年6月2日,对PubMed进行了系统检索。如果研究考察了COVID-19与OSA之间的关系,则纳入该研究。纳入的研究需为英文且有全文。本研究的结果表明,与OSA相关的许多风险因素和合并症,包括肥胖、高血压和糖尿病,都与COVID-19的不良结局相关。存在一些合理的机制,通过这些机制OSA可能独立增加个体与COVID-19相关的发病和死亡风险,并且新发表的CORONADO研究的数据表明,接受OSA治疗的患者可能死于COVID-19的风险增加。显然,这场大流行对OSA的治疗管理和诊断产生了重大影响,未来可能有必要为这些个体探索新的诊断和治疗途径。