Wu Xueliang, Yan Fuguo, Wang Likun, Sun Guangyuan, Liu Jinyu, Qu Ming, Wang Yicheng, Li Tian
Department of General Surgery, First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Department of General Surgery, Xinchang Hospital of Wenzhou Medical University, Xinchang, China.
Front Cell Dev Biol. 2020 Sep 2;8:812. doi: 10.3389/fcell.2020.00812. eCollection 2020.
MicroRNAs (miR) are single-stranded RNA of 21-23 nucleotides in length that repress mRNA translation and induces mRNA degradation. miR acts as an endogenous factor of gene expression and plays a crucial part in cancer biology such as cell development, proliferation, differentiation, and apoptosis. Numerous research has indicated that dysregulation of miR associates with colorectal carcinogenesis. In this review article, we firstly introduce the background of miR and colorectal cancer, and the mechanisms of miR in colorectal cancer, such as the proliferation, apoptosis, and progression. Then, we summarize the theranostic value of miR in colorectal cancer. Eventually, we discuss the potential directions and perspectives of miR. This article serves as a guide for further studies and implicate miR as a potent theranostic target for colorectal cancer.
微小RNA（miR）是长度为21 - 23个核苷酸的单链RNA，可抑制mRNA翻译并诱导mRNA降解。miR作为基因表达的内源性因子，在癌症生物学中发挥着关键作用，如细胞发育、增殖、分化和凋亡。大量研究表明，miR的失调与结直肠癌的发生有关。在这篇综述文章中，我们首先介绍miR和结直肠癌的背景，以及miR在结直肠癌中的作用机制，如增殖、凋亡和进展。然后，我们总结miR在结直肠癌中的诊疗价值。最后，我们讨论miR的潜在方向和前景。本文为进一步研究提供指导，并表明miR是结直肠癌有力的诊疗靶点。
Zotero 插件