术后并发症对乳腺癌手术后生存和复发的影响：系统评价和荟萃分析。
The effect of postoperative complications on survival and recurrence after surgery for breast cancer: A systematic review and meta-analysis.
机构信息
Clinical Research Fellow, Specialty Trainee (General Surgery), Academic Unit of Surgery, School of Medical, Veterinary and Life Sciences, University of Glasgow, Level 2 New Lister Building, Glasgow Royal Infirmary, 8-16 Alexandra Parade, Glasgow G31 2ER, United Kingdom.
Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1QH, United Kingdom.
出版信息
Crit Rev Oncol Hematol. 2020 Nov;155:103075. doi: 10.1016/j.critrevonc.2020.103075. Epub 2020 Aug 18.
BACKGROUND
This systematic review investigated the impact of complications on long term outcomes for patients with primary invasive operable breast cancer.
METHODS
A systematic review was performed using appropriate keywords, and meta-analysis using a random effects model completed.
RESULTS
Ten retrospective cohort studies, including 37,657 patients were included. Five studies identified a relationship between wound complications, infection and pyrexia and recurrence or recurrence-free survival. Risk of recurrence, 1-year and 5-year recurrence-free survival and overall survival were related to complications, particularly for patients with poor Nottingham Prognostic Index. Five studies failed to demonstrate a relationship between complications and prognosis. Complication was found to significantly affect 5-year recurrence-free survival (HR 1.48 95 % CI 1.02-2.14, p = 0.04) but not recurrence (HR 2.39, 95 %CI 0.94-6.07, p = 0.07), with a high degree of heterogeneity amongst analysed studies (I2 = 95 %).
DISCUSSION
Further research is needed to quantify the effects of postoperative complication on prognosis following surgery for breast cancer.
背景
本系统评价调查了并发症对原发性可手术浸润性乳腺癌患者长期结局的影响。
方法
使用适当的关键词进行系统评价，并使用随机效应模型进行荟萃分析。
结果
纳入了 10 项回顾性队列研究，共包括 37657 名患者。有 5 项研究确定了伤口并发症、感染和发热与复发或无复发生存之间的关系。复发风险、1 年和 5 年无复发生存率和总生存率与并发症相关，特别是对于诺丁汉预后指数较差的患者。有 5 项研究未能证明并发症与预后之间存在关系。并发症显著影响 5 年无复发生存率（HR 1.48，95%CI 1.02-2.14，p=0.04），但不影响复发（HR 2.39，95%CI 0.94-6.07，p=0.07），分析研究之间存在高度异质性（I2=95%）。
讨论
需要进一步研究来量化术后并发症对乳腺癌手术后预后的影响。
Zotero 插件