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β-内酰胺类抗生素过敏检测的长期影响配对病例对照研究。

Matched Case-Control Study of the Long-Term Impact of Beta-Lactam Antibiotic Allergy Testing.

机构信息

Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Melbourne, Australia

The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Australia.

出版信息

Antimicrob Agents Chemother. 2020 Nov 17;64(12). doi: 10.1128/AAC.01823-20.

Abstract

Whereas the short-term impacts of antibiotic allergy testing on delabeling and antibiotic usage have been demonstrated, the long-term impacts have been less well defined. In a single-center matched case-control study from Melbourne, Australia, we demonstrate that a beta-lactam antibiotic allergy testing program has a significant impact on antibiotic usage and infection-related outcomes. This study supports implementation of an antibiotic allergy testing program as a standard of care of antimicrobial stewardship programs.

摘要

尽管已经证明了抗生素过敏测试对去标签和抗生素使用的短期影响,但长期影响还不太明确。在澳大利亚墨尔本的一项单中心匹配病例对照研究中,我们证明了β-内酰胺类抗生素过敏测试计划对抗生素使用和感染相关结果有重大影响。这项研究支持将抗生素过敏测试计划作为抗生素管理计划的标准护理措施的实施。

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