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蛇咬伤中毒的长期后遗症:哥斯达黎加一家儿科医院的单中心回顾性研究

Long-term sequelae secondary to snakebite envenoming: a single centre retrospective study in a Costa Rican paediatric hospital.

作者信息

Brenes-Chacon Helena, Gutierrez Jose M, Camacho-Badilla Kattia, Soriano-Fallas Alejandra, Ulloa-Gutierrez Rolando, Valverde Kattia, Avila-Aguero María Luisa

机构信息

Universidad de Ciencias Medicas (UCIMED), San Jose, Costa Rica.

Caja Costarricense del Seguro Social (CCSS), Pediatric Infectious Diseases, Hospital Nacional de Niños "Dr. Carlos Saenz Herrera", San Jose, Costa Rica.

出版信息

BMJ Paediatr Open. 2020 Sep 16;4(1):e000735. doi: 10.1136/bmjpo-2020-000735. eCollection 2020.

Abstract

OBJECTIVES

Although devastating acute effects associated with snake envenoming are well described, the long-term sequelae resulting from these envenomings have not been adequately addressed, especially in the paediatric population. The aim of our study is to describe the clinical characteristics among paediatric patients in Costa Rica who developed long-term sequelae secondary to snakebite envenoming.

DESIGN

Retrospective descriptive study of paediatric patients under 13 years who were admitted with a history of a recent snakebite at the National Children's Hospital in Costa Rica from January 2001 to December 2014.

RESULTS

We enrolled 74 patients admitted to our centre due to envenoming, and separated those who did not develop sequelae (50 patients) from those who did (24 patients). Of those who presented acute complications during hospitalisation, local wound infection and clinically diagnosed compartmental syndrome were significantly higher in the group that developed sequelae thereafter. Hypertrophic scars (66.7%), functional limitation of affected limb (37.5%) and the need of skin graft (37.5%) were the most common sequelae. The median follow-up of patients with long-term sequelae after discharge was 25.4 months (5.6-59.4). No deaths were reported during this time period.

CONCLUSIONS

Given the high economic, personal and healthcare burden that entails follow-up of these patients, efforts should be carried out to prevent the factors associated with sequelae among the affected population.

摘要

目的

虽然与蛇咬伤相关的严重急性效应已有详尽描述,但这些咬伤所导致的长期后遗症尚未得到充分研究,尤其是在儿科人群中。我们研究的目的是描述哥斯达黎加儿科患者因蛇咬伤中毒而出现长期后遗症的临床特征。

设计

对2001年1月至2014年12月期间在哥斯达黎加国立儿童医院因近期有蛇咬伤史而入院的13岁以下儿科患者进行回顾性描述性研究。

结果

我们纳入了74名因中毒而入住本中心的患者,并将未出现后遗症的患者(50名)与出现后遗症的患者(24名)区分开来。在住院期间出现急性并发症的患者中,随后出现后遗症的组中局部伤口感染和临床诊断的骨筋膜室综合征显著更高。增生性瘢痕(66.7%)、患肢功能受限(37.5%)和需要植皮(37.5%)是最常见的后遗症。出院后有长期后遗症的患者的中位随访时间为25.4个月(5.6 - 59.4个月)。在此期间未报告死亡病例。

结论

鉴于对这些患者进行随访会带来高昂的经济、个人和医疗负担,应努力预防受影响人群中与后遗症相关的因素。

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