纯母乳喂养可降低极低出生体重儿严重脑室出血的发生率。
Exclusive human milk diet reduces incidence of severe intraventricular hemorrhage in extremely low birth weight infants.
机构信息
Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Division of Newborn Medicine, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, 11595, USA.
出版信息
J Perinatol. 2021 Mar;41(3):535-543. doi: 10.1038/s41372-020-00834-5. Epub 2020 Sep 30.
OBJECTIVE
Compare the incidence of severe (grade III/IV) intraventricular hemorrhage (IVH) and/or periventricular leukomalacia (PVL) between two groups of ELBW infants based on diet until 34 weeks corrected gestational age (CGA): (1) Exclusive human milk (EHM)-mother's own and/or pasteurized donor human milk, human milk-derived fortifier, and oral care with colostrum/human milk vs. (2) non-EHM-bovine formula or mother's own milk with bovine-derived fortifier.
STUDY DESIGN
Retrospective observational study of two groups of ELBW infants based on diet until 34 weeks CGA.
RESULT
There were n = 306 infants, 127 EHM and 179 non-EHM. Demographics and morbidities were similar except higher antenatal steroids and NEC in EHM group. The rate of severe IVH/PVL was lower in EHM compared to non-EHM group (7 vs. 18%, p < 0.006).
CONCLUSION
EHM diet had an independent neuroprotective effect and was associated with decreased incidence of severe IVH/PVL, supporting the need of EHM in ELBW infants.
目的
比较两组极低出生体重儿（ELBW）在 34 周校正胎龄（CGA）前基于饮食的严重（III/IV 级）脑室出血（IVH）和/或脑室周围白质软化（PVL）的发生率：（1）纯人乳（EHM）-母亲自身和/或巴氏消毒供体人乳、人乳来源的强化剂，以及用初乳/人乳进行口腔护理与（2）非 EHM-牛配方或含有牛来源强化剂的母亲自身奶。
研究设计
基于饮食直到 34 周 CGA 的两组 ELBW 婴儿的回顾性观察性研究。
结果
有 n = 306 名婴儿，127 名 EHM 和 179 名非 EHM。除 EHM 组接受更多的产前类固醇和 NEC 外，两组的人口统计学和发病情况相似。EHM 组严重 IVH/PVL 的发生率低于非 EHM 组（7%比 18%，p < 0.006）。
结论
EHM 饮食具有独立的神经保护作用，与严重 IVH/PVL 发生率降低相关，支持 ELBW 婴儿中使用 EHM。
Zotero 插件