咪唑并[1,2-]吡啶的多组分合成：通过黄素-碘偶联有机催化有氧氧化形成 C-N 和 C-S 键。
Multicomponent Synthesis of Imidazo[1,2-]pyridines: Aerobic Oxidative Formation of C-N and C-S Bonds by Flavin-Iodine-Coupled Organocatalysis.
机构信息
Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan.
出版信息
Org Lett. 2020 Oct 16;22(20):8002-8006. doi: 10.1021/acs.orglett.0c02929. Epub 2020 Oct 2.
PMID:33006477
Abstract
Herein, we report an aerobic oxidative C-N bond-forming process that enables the facile synthesis of imidazo[1,2-]pyridines and takes advantage of a coupled organocatalytic system that uses flavin and iodine. Furthermore, the dual catalytic system can be applied to the one-pot, three-step synthesis of 3-thioimidazo[1,2-]pyridines from aminopyridines, ketones, and thiols.
摘要
在此，我们报告了一种有氧氧化 C-N 键形成过程，该过程可实现咪唑并[1,2-a]吡啶的简便合成，并利用了黄素和碘的耦合有机催化体系。此外，该双催化体系可应用于从氨基吡啶、酮和硫醇一锅三步合成 3-硫代咪唑并[1,2-a]吡啶。
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