塑形之路：ATP 为 Hh 信号转导增添活力。
Getting in shape: ATP pumps up the volume in Hh signalling.
机构信息
Peter MacCallum Cancer Institute, Melbourne, Vic., Australia.
出版信息
EMBO J. 2020 Nov 2;39(21):e106564. doi: 10.15252/embj.2020106564. Epub 2020 Oct 6.
Abstract
Glycolysis is a major metabolic process which ensures the break down of glucose into pyruvate via multiple enzymatic steps, but if and how this catabolism can impact on developmental patterning is unclear. In this issue, Spannl et al (2020) demonstrate a novel link between energy metabolism and tissue formation in the fly imaginal discs. They show that ATPs generated via glycolysis maintain active transport of a smoothened inhibitor, which keeps Hh signalling in check to preserve the correct shape and proportion of the developing wing.
摘要
糖酵解是一种主要的代谢过程，通过多个酶促步骤确保葡萄糖分解为丙酮酸，但这种分解代谢如何以及是否能影响发育模式尚不清楚。在本期杂志中，Spannl 等人（2020 年）展示了果蝇的成虫盘的能量代谢和组织形成之间的新联系。他们表明，糖酵解产生的 ATP 维持着 smoothened 抑制剂的主动运输，从而抑制 Hh 信号，以保持发育中翅膀的正确形状和比例。
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