甲状旁腺功能减退患者的动态硫醇/二硫键稳态与氧化状态
Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism.
作者信息
Or Koca Arzu, Dağdeviren Murat, Akkan Tolga, Ateş İhsan, Neşelioğlu Salim, Erel Özcan, Altay Mustafa
机构信息
University of Health Sciences, Keçiören Health Administration and Research Centre, Department of Endocrinology and Metabolism, Ankara, Turkey.
University of Health Sciences, Numune Health Administration and Research Centre, Department of Internal Medicine, Ankara, Turkey.
出版信息
J Med Biochem. 2020 Jan 23;39(2):231-239. doi: 10.2478/jomb-2019-0036.
BACKGROUND
In this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels.
METHODS
55 patients with iatrogenic hypoparathyroidism follow-ups and 40 healthy volunteers were included in the study. The blood dynamic thiol/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples.
RESULTS
In our study, it was found that the disulfide, disulfide/native thiol, disulfide/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25-hydroxy vitamin D (25-OH vitamin D) and disulfide, disulfide/native thiol and disulfide/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated.
CONCLUSIONS
Consequently, a change in favour of disulfide was found in the dynamic thiol-disulfide homeostasis in the hypoparathyroidism group in our study.
背景
在本研究中，我们旨在确定动态硫醇/二硫键稳态和氧化还原平衡，并研究这些参数与疾病严重程度和血清钙水平之间的关系。
方法
本研究纳入了55例接受随访的医源性甲状旁腺功能减退患者和40名健康志愿者。测定血清样本中的血液动态硫醇/二硫键平衡、总抗氧化状态（TAS）、总氧化状态（TOS）、对氧磷酶活性（PON）水平。
结果
在我们的研究中，发现甲状旁腺功能减退组的二硫键、二硫键/天然硫醇、二硫键/总硫醇水平较高。发现25-羟基维生素D（25-OH维生素D）与二硫键、二硫键/天然硫醇和二硫键/总硫醇之间呈负相关，天然硫醇与总硫醇比值之间呈正相关；校正钙水平与PON水平呈负相关。
结论
因此，在我们的研究中，甲状旁腺功能减退组的动态硫醇-二硫键稳态出现了有利于二硫键的变化。
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