章鱼胺神经肽调节 …… 的睡眠。
Orcokinin neuropeptides regulate sleep in .
机构信息
Department of Biology, Saint Joseph's University, Philadelphia, PA, USA.
出版信息
J Neurogenet. 2020 Sep-Dec;34(3-4):440-452. doi: 10.1080/01677063.2020.1830084. Epub 2020 Oct 12.
Abstract
Orcokinin neuropeptides are conserved among ecdysozoans, but their functions are incompletely understood. Here, we report a role for orcokinin neuropeptides in the regulation of sleep in the nematode . The orcokinin peptides, which are encoded by the and genes, are necessary and sufficient for quiescent behaviors during developmentally timed sleep (DTS) as well as during stress-induced sleep (SIS). The five orcokinin neuropeptides encoded by have distinct but overlapping functions in the regulation of movement and defecation quiescence during SIS. We suggest that orcokinins may regulate behavioral components of sleep-like states in nematodes and other ecdysozoans.
摘要
蜕皮动物门中保守存在的奥克金神经肽，但它们的功能尚未完全了解。在这里，我们报告了奥克金神经肽在调控线虫睡眠中的作用。由 和 基因编码的奥克金肽对于发育定时睡眠（DTS）和应激诱导睡眠（SIS）期间的静止行为是必需和充分的。由 编码的 5 种奥克金神经肽在 SIS 期间调节运动和排粪静止方面具有不同但重叠的功能。我们认为，奥克金可能调节线虫和其他蜕皮动物类似睡眠状态的行为成分。
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