美国全国范围内跨性别男性和女性的 PrEP 接受和停药情况。
PrEP Uptake and Discontinuation Among a U.S. National Sample of Transgender Men and Women.
机构信息
Department of Public Health Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA.
Center for AIDS Intervention Research, Medical College of Wisconsin, Milwaukee, WI, USA.
出版信息
AIDS Behav. 2021 Apr;25(4):1063-1071. doi: 10.1007/s10461-020-03064-0. Epub 2020 Oct 15.
Abstract
Pre-exposure prophylaxis (PrEP) has revolutionized HIV prevention efforts by effectively preventing the sexual transmission of HIV infection. Few studies have examined PrEP uptake and discontinuation among transgender individuals who are underserved in HIV prevention efforts. An online U.S. nationwide survey screened 294 HIV-negative transgender people for participation in a larger cohort study. We analyzed associations between demographic characteristics and PrEP use and discontinuation. We conducted thematic analyses of open-ended responses to identify reasons for PrEP discontinuation. Fifty-one participants (17.4%) reported ever receiving a PrEP prescription. Transgender men reported higher PrEP use than transgender women (χ = 18.06; p < 0.0001). PrEP discontinuation was reported by 49.0% of individuals who reported PrEP use. Reasons for PrEP discontinuation were related to side effects, insurance coverage, relationship status, and access to providers. HIV prevention efforts to increase PrEP should include mechanisms for PrEP uptake and re-initiation among transgender individuals.
摘要
暴露前预防 (PrEP) 通过有效预防 HIV 感染的性传播，彻底改变了 HIV 预防工作。几乎没有研究调查过在 HIV 预防工作中服务不足的跨性别者中 PrEP 的采用和停药情况。一项美国全国性在线调查筛选了 294 名 HIV 阴性的跨性别者，以参与更大的队列研究。我们分析了人口统计学特征与 PrEP 使用和停药之间的关联。我们对开放式回答进行了主题分析，以确定 PrEP 停药的原因。51 名参与者（17.4%）报告曾收到 PrEP 处方。跨性别男性比跨性别女性报告 PrEP 的使用率更高（χ = 18.06；p < 0.0001）。报告使用 PrEP 的人中，有 49.0%的人报告 PrEP 停药。PrEP 停药的原因与副作用、保险覆盖范围、关系状况和获得提供者的机会有关。增加 PrEP 的 HIV 预防工作应包括为跨性别者提供 PrEP 采用和重新启动的机制。
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