Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
J Mol Neurosci. 2021 May;71(5):991-998. doi: 10.1007/s12031-020-01721-6. Epub 2020 Oct 15.
Long non-coding RNAs (lncRNAs) have crucial roles in the pathogenesis of immune-related disorders. However, their role in the pathobiology of inflammatory demyelinating polyradiculoneuropathies remains unclear. In the current study, we measured peripheral expression of four lncRNAs, namely TUG1, FAS-AS1, NEAT1, and GAS5, in patients with acute/chronic inflammatory demyelinating polyradiculoneuropathies (AIDP/CIDP) compared with healthy subjects. Notably, all lncRNAs were over-expressed in patients compared with controls (P < 0.0001 for all lncRNAs). When assessing their expressions in AIDP and CIDP groups separately, TUG1 and NEAT1 were up-regulated in both patient groups compared with controls, yet FAS-AS1 and GAS5 were only up-regulated in CIDP cases. There were remarkable pairwise correlations between expression levels of these lncRNAs in all study groups. Based on the above-mentioned data, we suggest participation of these for lncRNAs in the pathogenesis of inflammatory demyelinating polyradiculoneuropathies. Moreover, FAS-AS1 and GAS5 lncRNAs have type-specific roles in this regard. Future functional studies are needed to elaborate the molecular mechanisms of the contribution of these transcripts in AIDP/CIDP.
长链非编码 RNA（lncRNAs）在免疫相关疾病的发病机制中具有重要作用。然而，它们在炎症性脱髓鞘性多发性神经根神经病的病理生物学中的作用尚不清楚。在本研究中，我们测量了急性/慢性炎症性脱髓鞘性多发性神经根神经病（AIDP/CIDP）患者与健康受试者相比外周血中四种 lncRNA（TUG1、FAS-AS1、NEAT1 和 GAS5）的表达。值得注意的是，与对照组相比，所有 lncRNA 在患者中均过度表达（所有 lncRNA 的 P < 0.0001）。当分别评估 AIDP 和 CIDP 组的表达时，TUG1 和 NEAT1 在两组患者中均上调，而 FAS-AS1 和 GAS5 仅在 CIDP 病例中上调。在所有研究组中，这些 lncRNA 的表达水平之间存在显著的两两相关性。基于上述数据，我们提出这些 lncRNA 参与了炎症性脱髓鞘性多发性神经根神经病的发病机制。此外，FAS-AS1 和 GAS5 lncRNA 在这方面具有特定类型的作用。需要进一步的功能研究来阐述这些转录物在 AIDP/CIDP 中的作用的分子机制。
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