NK 细胞介导的神经母细胞瘤细胞裂解被来自小儿发作性眼球运动-肌阵挛综合征患者的 IgG 增强。
NK Cell-mediated Neuroblastoma Cell Lysis is Enhanced by IgG From Patients With Pediatric Opsoclonus-Myoclonus Syndrome.
机构信息
Departments of Neurology.
Department of Pediatric Oncology, University of Cologne, Cologne.
出版信息
J Pediatr Hematol Oncol. 2021 Mar 1;43(2):e176-e179. doi: 10.1097/MPH.0000000000001953.
Pediatric opsoclonus-myoclonussyndrome (OMS) is a rare autoimmune disorder of which 50% are associated with neuroblastoma (NB). We investigated whether surface-binding autoantibodies in OMS can enhance natural killer (NK) cell-mediated cytotoxicity in these patients. OMS immunoglobulin G (IgG) bound to NB cell lines and NK cell-mediated cytotoxicity to NB cells was enhanced after preincubation with OMS-IgG, but not IgG from NB without OMS or healthy controls. Activation of NK cells by surface-binding autoantibodies may be an additional mechanism of antitumor immunity in children with NB and OMS.
小儿发作性眼球运动-肌阵挛综合征（OMS）是一种罕见的自身免疫性疾病，其中 50%与神经母细胞瘤（NB）有关。我们研究了 OMS 中的表面结合自身抗体是否可以增强这些患者的自然杀伤（NK）细胞介导的细胞毒性。OMS 免疫球蛋白 G（IgG）与 NB 细胞系结合，并且在用 OMS-IgG 预孵育后，NK 细胞对 NB 细胞的介导的细胞毒性增强，但 NB 中无 OMS 或健康对照的 IgG 则没有。表面结合自身抗体激活 NK 细胞可能是 NB 和 OMS 儿童抗肿瘤免疫的另一种机制。
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