Calderón Guzmán David, Juárez Olguín Hugo, Veloz Corona Quetzalli, Ortiz Herrera Maribel, Osnaya Brizuela Norma, Barragán Mejía Gerardo
Laboratory of Neurosciences, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
Laboratory of Pharmacology, INP, Mexico City, Mexico.
Diabetes Metab Syndr Obes. 2020 Oct 2;13:3481-3486. doi: 10.2147/DMSO.S270564. eCollection 2020.
Several risks for diseases, such as atherosclerosis, renal diseases, and diabetes, have inextricably been linked with obesity. Nowadays, this health-risk-laden disease is being managed with assorted types of drugs, some of which guarantee modest benefits. The chronic inflammatory effect of obesity has a negative effect in insulin signaling, a situation attributable to insulin resistance that culminates in high blood sugar inputs seen in diseases such as type 2 diabetes and metabolic syndrome. Food such as beans with different bioactive compounds could reduce the risk of diabetic complications. Demand for bean products is growing because of its robust contents of several health-promoting components, eg, saponins. Saponins are characterized by containing lower glucose and cholesterol levels and have been doted with antioxidant activities, as well as anti-inflammatory and anti-diabetic effects. In this writing, the attributes of saponins in providing substantial health and nutritional benefits in humans, as well as in improving and ameliorating diabetic complications, were reviewed.
多种疾病风险,如动脉粥样硬化、肾脏疾病和糖尿病,都与肥胖有着千丝万缕的联系。如今,这种充满健康风险的疾病正通过各种类型的药物进行治疗,其中一些药物能带来一定的益处。肥胖的慢性炎症效应会对胰岛素信号传导产生负面影响,这种情况归因于胰岛素抵抗,最终导致在2型糖尿病和代谢综合征等疾病中出现高血糖输入。诸如豆类等含有不同生物活性化合物的食物可以降低糖尿病并发症的风险。由于豆类产品含有多种促进健康的成分,如皂苷,其需求正在不断增长。皂苷的特点是含有较低的葡萄糖和胆固醇水平,并具有抗氧化活性以及抗炎和抗糖尿病作用。在本文中,对皂苷在为人类提供实质性健康和营养益处以及改善糖尿病并发症方面的特性进行了综述。