使用雷莫西尤单抗导致拔牙创口愈合延迟。
Delayed Healing of Tooth Extraction Sockets with Ramucirumab Use.
作者信息
Iijima Yosuke, Yamada Miki, Hino Shunsuke, Sano Motohiko, Kaneko Takahiro, Horie Norio
机构信息
Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Division of Applied Pharmaceutical Education and Research Hoshi University, Tokyo, Japan.
出版信息
Case Rep Dent. 2020 Sep 30;2020:8881749. doi: 10.1155/2020/8881749. eCollection 2020.
OBJECTIVE
An angiogenesis inhibitor can cause medication-related osteonecrosis of the jaw (MRONJ). To our knowledge, there has been no report that an angiogenesis inhibitor causes delayed healing of tooth extraction socket. Here, we describe a case of delayed healing of tooth extraction sockets associated with an angiogenesis inhibitor, ramucirumab, which showed characteristics similar to MRONJ.
MATERIALS AND METHODS
A 76-year-old male patient, who was diagnosed with gastric cancer with liver metastasis, received tooth extraction twice during continuous chemotherapy comprising paclitaxel and ramucirumab.
RESULTS
The first extraction was performed 30 days after ramucirumab discontinuation without complication. The second extraction was conducted without ramucirumab discontinuation. Although tooth socket healing was finally achieved, it took about 150 days. . This case was considered to be delayed healing of dry sockets rather than MRONJ due to ramucirumab. Dentists and oral surgeons need to be aware that angiogenesis inhibitors can cause not only MRONJ but also dry sockets after tooth extraction.
目的
血管生成抑制剂可导致药物相关性颌骨坏死（MRONJ）。据我们所知，尚无血管生成抑制剂导致拔牙创愈合延迟的报道。在此，我们描述一例与血管生成抑制剂雷莫西尤单抗相关的拔牙创愈合延迟病例，该病例表现出与MRONJ相似的特征。
材料与方法
一名76岁男性患者，被诊断为胃癌伴肝转移，在接受包括紫杉醇和雷莫西尤单抗的持续化疗期间接受了两次拔牙。
结果
第一次拔牙在停用雷莫西尤单抗30天后进行，无并发症。第二次拔牙未停用雷莫西尤单抗。尽管拔牙创最终愈合，但耗时约150天。该病例被认为是干槽症愈合延迟，而非雷莫西尤单抗导致的MRONJ。牙医和口腔外科医生需要意识到血管生成抑制剂不仅可导致MRONJ，还可导致拔牙后干槽症。
Zotero 插件