Ali Arif Maqsood, Waseem Gule Raana, Arif Shazia
Department of Pathology and Blood Bank, Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan.
Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan.
Access Microbiol. 2019 Nov 1;2(1):acmi000076. doi: 10.1099/acmi.0.000076. eCollection 2020.
Infective endocarditis (IE) is an uncommon but life-threatening infection. It is commonly associated with diseased or damaged valves. Patients with congenital heart disease are more prone to getting IE than the general population. The typical organisms that cause IE include , , and . However, the importance of rare micro-organisms like should not be underestimated especially when isolated from multiple blood cultures in patients suspected of IE.
We report a rare case of right-sided infective endocarditis due to in a young non-diabetic, non-addict female of low socioeconomic class who presented with undiagnosed fever for 1 year. She was investigated and treated for fever by several general practitioners without relief. Later on, she was diagnosed by a local cardiologist to have perimembranous ventricular septal defect with a small pulmonary valve vegetation. She was referred to a tertiary care cardiac hospital in Rawalpindi, Pakistan for further management. Transthoracic and transesophageal echocardiography confirmed IE secondary to preexisting congenital heart disease complicated with a small pulmonary vegetation. Her blood cultures yielded growth of a rare micro-organism to cause IE. The patient responded to the antibiotic therapy.
Clinicians should have a high index of suspicion for IE as a possible cause of a prolonged fever especially in the presence of congenital heart disease. Antibiotic susceptibility is required for adequate therapy.
感染性心内膜炎(IE)是一种罕见但危及生命的感染。它通常与病变或受损的瓣膜相关。先天性心脏病患者比普通人群更容易患IE。引起IE的典型病原体包括 、 、 和 。然而,像 这样的罕见微生物的重要性不应被低估,特别是当从疑似IE的患者的多次血培养中分离出来时。
我们报告了一例罕见的右侧感染性心内膜炎病例,病因是 ,患者为一名年轻的非糖尿病、非成瘾女性,社会经济地位较低,出现未确诊的发热1年。她曾由几位全科医生进行检查和治疗,但发热未缓解。后来,当地一名心脏病专家诊断她患有膜周部室间隔缺损伴小的肺动脉瓣赘生物。她被转诊至巴基斯坦拉瓦尔品第的一家三级心脏专科医院进行进一步治疗。经胸和经食管超声心动图证实IE继发于先前存在的先天性心脏病,并伴有小的肺动脉赘生物。她的血培养结果显示生长出 ,这是一种罕见的引起IE的微生物。患者对抗生素治疗有反应。
临床医生应高度怀疑 性IE可能是长期发热的原因,尤其是在存在先天性心脏病的情况下。充分治疗需要抗生素敏感性检测。