Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87574, United States of America.
Nuclear Security and Isotope Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States of America.
Nucl Med Biol. 2020 Nov-Dec;90-91:69-73. doi: 10.1016/j.nucmedbio.2020.09.006. Epub 2020 Sep 30.
Thorium-226 (half-life 30.6 m) is a radionuclide of interest for use in targeted alpha therapy applications. Due to its short half-life, Th must be provided through a radionuclide generator system from its parent U (20.8 d). Furthermore, as the half-life of Th is very short, it should be provided in a form that is directly amenable to use in biomedical applications.
A reverse radionuclide generator system was developed employing a DGA extraction chromatography column. A U/Th parent/daughter solution in equilibrium is added to a DGA column in >6 M HCl. The parent U is eluted first in 0.1 M HNO followed by elution of Th in 0.1 M citrate buffer pH 5.
Thorium-226 was recovered from the radionuclide generator column with >96% yield. Greater than 99.5% of the U parent was isolated for reuse in the generator. Long term evaluation over six weeks demonstrated consistent supply of Th with greater than 99.5% radionuclidic purity. The only contaminant found in the final product was U (<0.5%).
The reverse radionuclide generator described herein was shown to be a feasible method for providing Th in high yield, purity and in a chemical form that is amenable for direct use in biomedical applications.
钍-226（半衰期 30.6 m）是一种放射性核素，可用于靶向 alpha 治疗应用。由于其半衰期短，必须通过放射性核素发生器系统从其母铀（20.8 天）提供。此外，由于钍的半衰期非常短，它应该以直接适用于生物医学应用的形式提供。
开发了一种反放射性核素发生器系统，采用 DGA 萃取色谱柱。将处于平衡状态的 U/Th 母/子溶液加入到>6 M HCl 中的 DGA 柱中。首先用 0.1 M HNO 洗脱母铀，然后用 0.1 M 柠檬酸盐缓冲液 pH 5 洗脱 Th。
从放射性核素发生器柱中以>96%的产率回收了钍-226。大于 99.5%的 U 母被分离出来，可重新用于发生器。六周以上的长期评估表明，Th 的供应稳定，放射性核纯度大于 99.5%。最终产物中仅发现 U（<0.5%）为污染物。
本文所述的反放射性核素发生器是一种可行的方法，可高产率、高纯度地提供钍，并以直接适用于生物医学应用的化学形式提供。
Zotero 插件