Liu Tingting, Cao Lixia, Zhang Tingting, Fu Huan
Department of Hematology, People's Hospital of Jiangxi Province, Nanchang, Jiangxi, China.
Department of Hematology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China.
Arch Physiol Biochem. 2023 Apr;129(2):405-415. doi: 10.1080/13813455.2020.1828483. Epub 2020 Oct 19.
In this research, we explored their capacity for Narcissoside antioxidant and anticholinergic, antidiabetic, and anti-acute myeloid leukaemia. Narcissoside's antioxidant activities were elucidated by the use of various bioanalytical assays. Narcissoside's radical scavenging activities were evaluated by DPPH and ABTS scavenging activities. On the other hand, IC values were calculated for DPPH, and ABTS scavenging, acetylcholinesterase, and α-glucosidase inhibition effects of narcissoside. IC values narcissoside, as 11.54 nM for AChE and 65.58 nM for α-glucosidase were calculated with % Activity-[Inhibitory] graphs. Then, ADME/T analysis of narcissoside molecule was performed to calculate the drug becoming parameters.
在本研究中,我们探究了水仙苷的抗氧化、抗胆碱能、抗糖尿病和抗急性髓系白血病的能力。通过各种生物分析方法阐明了水仙苷的抗氧化活性。通过DPPH和ABTS清除活性评估了水仙苷的自由基清除活性。另一方面,计算了水仙苷对DPPH、ABTS清除、乙酰胆碱酯酶和α-葡萄糖苷酶的抑制作用的IC值。利用%活性-[抑制]图计算出水仙苷对乙酰胆碱酯酶的IC值为11.54 nM,对α-葡萄糖苷酶的IC值为65.58 nM。然后,对水仙苷分子进行了ADME/T分析以计算药物成药性参数。