老年人视网膜血管网络与神经纤维层的相关性：蒙塔谢特研究。
Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study.
机构信息
Department of Ophthalmology, University Hospital, Dijon, France.
INSERM, CIC1432, Clinical Epidemiology Unit, Dijon, France.
出版信息
PLoS One. 2020 Oct 21;15(10):e0241055. doi: 10.1371/journal.pone.0241055. eCollection 2020.
PURPOSE
To investigate the association between the characteristics of the retinal vascular network in the elderly and retinal nerve fiber layer (RNFL) thickness in a population-based study.
METHODS
We conducted a population-based study, the Montrachet study (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease), in participants aged ≥ 75 years. RNFL thickness was assessed with spectral-domain optical coherence tomography (SD-OCT). Analysis of the retinal vascular network was performed by means of the Singapore "I" Vessel Assessment (SIVA) software based on fundus photography.
RESULTS
Data from 970 participants were suitable for analysis. Patients with optic neuropathy were excluded. In multivariable analysis, each standard deviation (SD) decrease in the caliber of the six largest arterioles and veins in zone B and the six largest arterioles and veins in zone C was associated with a decrease in global RNFL thickness (β = -1.62 μm, P = 0.001; β = -2.39 μm, P < 0.001; β = -1.56 μm, P = 0.002; and β = -2.64 μm, P < 0.001, respectively).
CONCLUSIONS
Our study found that decreased retinal vessels caliber were associated with a decreased RNFL thickness in the elderly without optic neuropathy.
目的
在一项基于人群的研究中，调查老年人视网膜血管网络特征与视网膜神经纤维层（RNFL）厚度之间的关系。
方法
我们进行了一项基于人群的研究，即 Montrachet 研究（Maculopathy Optic Nerve，nuTRition neurovAsCular，和 HEarT disease），参与者年龄均≥75 岁。采用频域光相干断层扫描（SD-OCT）评估 RNFL 厚度。通过基于眼底摄影的新加坡“I”血管评估（SIVA）软件分析视网膜血管网络。
结果
970 名参与者的数据适合进行分析。排除了视神经病变患者。多变量分析显示，B 区和 C 区最大的 6 条动脉和静脉的口径每标准偏差（SD）下降，与全层 RNFL 厚度下降相关（β=-1.62μm，P=0.001；β=-2.39μm，P<0.001；β=-1.56μm，P=0.002；β=-2.64μm，P<0.001）。
结论
本研究发现，老年人视网膜血管口径减小与无视神经病变的 RNFL 厚度减小有关。
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