Ramos-Lopez Omar, Daimiel Lidia, Ramírez de Molina Ana, Martínez-Urbistondo Diego, Vargas Juan A, Martínez J Alfredo
Faculty of Medicine and Psychology, Autonomous University of Baja California, Tijuana, Baja California, Mexico.
Nutritional Control of the Epigenome Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain.
Int J Genomics. 2020 Oct 19;2020:6901217. doi: 10.1155/2020/6901217. eCollection 2020.
To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans.
This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria.
Twenty-nine polymorphisms located in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified.
Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments.
系统探索与人类严重急性呼吸综合征冠状病毒（SARS-CoV）感染临床结局相关的基因多态性。
按照系统评价与Meta分析方案报告规范（PRISMA-P）指南和PICO/AXIS标准，在PubMed/Medline和SCOPUS数据库中全面检索已发表的英文论文。
在21个基因中发现了29个多态性，这些多态性主要在亚洲人群中与SARS-CoV易感性/抗性、疾病严重程度和临床结局相关。因此，确定了参与关键病理生理过程的基因，如与病毒进入细胞的机制以及抗病毒免疫/炎症反应相关的机制。
尽管必须谨慎，但该系统评价的结果表明，多种基因多态性通过影响病毒发病机制和宿主免疫反应与SARS-CoV感染特征相关，这对于严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）/冠状病毒病（COVID-19）遗传学的研究和理解以及根据所研究人群和相关环境进行个性化转化临床实践可能具有重要应用价值。
