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新型神经技术干预儿科耐药性癫痫:医生观点。

Novel Neurotechnological Interventions for Pediatric Drug-Resistant Epilepsy: Physician Perspectives.

机构信息

8166University of British Columbia, Division of Neurology, Department of Medicine, Vancouver, British Columbia, Canada.

Division of Neurosurgery, Department of Surgery, 8166University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

J Child Neurol. 2021 Mar;36(3):222-229. doi: 10.1177/0883073820966935. Epub 2020 Oct 28.

Abstract

This qualitative study investigated factors that guide physicians' choices for minimally invasive and neuromodulatory interventions as alternatives to conventional surgery or medical management for pediatric drug-resistant epilepsy. North American physicians were recruited to one of 4 focus groups at national conferences. Discussions were analyzed using qualitative content analysis. A pragmatic neuroethics framework was applied to interpret results. Discussions revealed 2 major thematic branches: (1) clinical decision making and (2) ethical considerations. Under clinical decision making, physicians emphasized scientific evidence and patient candidacy when assessing neurotechnologies for patients. Ongoing seizures without intervention was important for safety and neurodevelopment. Under ethical considerations, resource allocation, among other financial considerations for technology adoption, were considerable sources of pressure on decision making. Access to neurotechnology was a salient theme differentiating Canadian and American contexts. When assessing novel neurotechnological interventions for pediatric drug-resistant epilepsy, physicians balance clinical and ethical factors to guide decision making and best practice.

摘要

这项定性研究调查了指导医生选择微创和神经调节干预的因素,这些干预可作为小儿耐药性癫痫的传统手术或药物治疗的替代方法。在全国会议上,招募了来自北美的医生参加了 4 个焦点小组之一。使用定性内容分析对讨论进行了分析。应用实用神经伦理学框架来解释结果。讨论揭示了两个主要的主题分支:(1)临床决策制定和(2)伦理考虑。在临床决策制定下,医生在评估神经技术对患者的适用性时强调科学证据和患者的候选资格。持续发作而不干预对于安全性和神经发育至关重要。在伦理考虑下,资源分配以及技术采用的其他财务考虑因素是决策的主要压力来源。神经技术的可及性是区分加拿大和美国背景的一个突出主题。在评估小儿耐药性癫痫的新型神经技术干预时,医生权衡临床和伦理因素以指导决策和最佳实践。

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