抗胰岛素抗体对胰岛素治疗的糖尿病患者血糖控制的影响。

Effect of anti-insulin antibodies on glycemic control in insulin treated diabetic patients.

作者信息

Sakata S, Matsuda M, Komaki T, Miura K

机构信息

Third Department of Internal Medicine, Gifu University School of Medicine, Japan.

出版信息

Immunol Invest. 1987 May;16(3):263-71. doi: 10.3109/08820138709030580.

DOI:10.3109/08820138709030580

PMID:3311984

Abstract

In order to examine the effect of anti-insulin antibodies on serum insulin concentration and glycemic control, sera from 49 insulin-treated diabetic patients (20 males and 29 females) were examined for their titer of anti-insulin antibodies, and concentrations of total insulin (TIRI), free insulin (FIRI) and hemoglobin A1c. Titer of anti-insulin antibodies correlated only with TIRI (r = 0.72, p less than 0.001) and did not correlate with duration of insulin treatment, FIRI concentration, daily dose of insulin, or HbA1c concentration. These results indicate that elevated titer of anti-insulin antibodies in patients under insulin therapy, (1) increases total serum insulin concentration but does not affect serum free insulin level, and (2) has little effect, if any, on glycemic control and the required daily dose of insulin.

摘要

为了研究抗胰岛素抗体对血清胰岛素浓度和血糖控制的影响，检测了49例接受胰岛素治疗的糖尿病患者（20例男性和29例女性）血清中的抗胰岛素抗体滴度、总胰岛素（TIRI）浓度、游离胰岛素（FIRI）浓度和糖化血红蛋白A1c。抗胰岛素抗体滴度仅与总胰岛素浓度相关（r = 0.72，p < 0.001），与胰岛素治疗时长、游离胰岛素浓度、每日胰岛素剂量或糖化血红蛋白A1c浓度均无相关性。这些结果表明，胰岛素治疗患者中抗胰岛素抗体滴度升高，（1）会增加血清总胰岛素浓度，但不影响血清游离胰岛素水平；（2）对血糖控制和每日所需胰岛素剂量几乎没有影响（若有影响也极小）。