RASA1 在癌症中的作用：综述与更新（综述）。
Role of RASA1 in cancer: A review and update (Review).
机构信息
Department of Oncology, First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, P.R. China.
Qinghai Institute of Health Sciences, Xining, Qinghai 810000, P.R. China.
出版信息
Oncol Rep. 2020 Dec;44(6):2386-2396. doi: 10.3892/or.2020.7807. Epub 2020 Oct 13.
Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/ERK or Ras/PI3K/AKT signalling. Moreover, miRNAs are capable of regulating RASA1 and could be a novel targeted treatment strategy for tumours.
Ras p21 蛋白激活因子 1（RASA1）是 Ras GDP 和 GTP 的调节剂，参与许多生理过程，如血管生成、细胞增殖和细胞凋亡。因此，RASA1 也有助于血管疾病和肿瘤形成的病理过程。本综述重点介绍了 RASA1 在肺部、肠道、肝脏和乳房的多种肿瘤类型中的作用。此外，我们还讨论了 RASA1 及其下游通过 Ras/RAF/MEK/ERK 或 Ras/PI3K/AKT 信号转导的潜在机制。此外，miRNA 能够调节 RASA1，可能成为肿瘤的一种新的靶向治疗策略。
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