肿瘤微环境中的免疫代谢相互作用
Immunometabolic Interplay in the Tumor Microenvironment.
作者信息
Kaymak Irem, Williams Kelsey S, Cantor Jason R, Jones Russell G
机构信息
Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
出版信息
Cancer Cell. 2021 Jan 11;39(1):28-37. doi: 10.1016/j.ccell.2020.09.004. Epub 2020 Oct 29.
Immune cells' metabolism influences their differentiation and function. Given that a complex interplay of environmental factors within the tumor microenvironment (TME) can have a profound impact on the metabolic activities of immune, stromal, and tumor cell types, there is emerging interest to advance understanding of these diverse metabolic phenotypes in the TME. Here, we discuss cell-extrinsic contributions to the metabolic activities of immune cells. Then, considering recent technical advances in experimental systems and metabolic profiling technologies, we propose future directions to better understand how immune cells meet their metabolic demands in the TME, which can be leveraged for therapeutic benefit.
免疫细胞的代谢会影响其分化和功能。鉴于肿瘤微环境（TME）中环境因素的复杂相互作用会对免疫、基质和肿瘤细胞类型的代谢活动产生深远影响，人们越来越有兴趣深入了解TME中这些多样的代谢表型。在此，我们讨论细胞外因素对免疫细胞代谢活动的影响。然后，考虑到实验系统和代谢分析技术的最新技术进展，我们提出了未来的研究方向，以更好地理解免疫细胞如何在TME中满足其代谢需求，这可用于治疗获益。
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