不同背景下血清甲胎蛋白（AFP）和异常凝血酶原（DCP）水平在早期乙肝相关肝细胞癌诊断中的评估
Evaluation of serum AFP and DCP levels in the diagnosis of early-stage HBV-related HCC under different backgrounds.
作者信息
Song Ting, Wang Lili, Xin Ruopei, Zhang Liping, Tian Yun
机构信息
Department of Hepatology, The Sixth People's Hospital of Qingdao, Qingdao, Shandong, China.
Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
出版信息
J Int Med Res. 2020 Oct;48(10):300060520969087. doi: 10.1177/0300060520969087.
OBJECTIVE
This study compared the diagnostic performance of alpha-fetoprotein (AFP) and des-gamma-carboxyprothrombin (DCP) in early-stage hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) under different backgrounds.
METHODS
Patients were enrolled and divided in four groups: chronic HBV infection (CHB), liver cirrhosis (LC), early-stage CHB-HCC, and early-stage LC-HCC. Serum AFP and DCP levels were measured. Receiver-operating characteristic (ROC) curve and area under the curve (AUC) analyses were applied to compare the diagnostic performance of DCP and AFP for HCC.
RESULTS
In total, 200 patients were enrolled, including 48, 64, 33, and 55 patients with CHB, LC, CHB-HCC, and LC-HCC, respectively. ROC curve analysis revealed that the AUCs of AFP, DCP, and their combination in differentiating early-stage LC-HCC from LC were 0.776, 0.758, and 0.786, respectively. The values of these markers in discriminating early-stage CHB-HCC from CHB were 0.828, 0.731, and 0.862, respectively.
CONCLUSIONS
DCP was inferior to AFP in differentiating early-stage CHB-HCC from CHB. However, AFP and DCP displayed similar performance in distinguishing early-stage LC-HCC and LC.
目的
本研究比较了甲胎蛋白（AFP）和异常凝血酶原（DCP）在不同背景下对早期乙型肝炎病毒相关肝细胞癌（HBV-HCC）的诊断性能。
方法
招募患者并分为四组：慢性HBV感染（CHB）、肝硬化（LC）、早期CHB-HCC和早期LC-HCC。检测血清AFP和DCP水平。应用受试者操作特征（ROC）曲线和曲线下面积（AUC）分析来比较DCP和AFP对HCC的诊断性能。
结果
总共招募了200例患者，分别包括48例、64例、33例和55例CHB、LC、CHB-HCC和LC-HCC患者。ROC曲线分析显示，AFP、DCP及其联合检测在区分早期LC-HCC与LC时的AUC分别为0.776、0.758和0.786。这些标志物在区分早期CHB-HCC与CHB时的值分别为0.828、0.731和0.862。
结论
在区分早期CHB-HCC与CHB方面，DCP不如AFP。然而，AFP和DCP在区分早期LC-HCC与LC时表现相似。
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