十阳离子柱[5]芳烃：一种用于开发氙磁共振成像剂的新型支架。
Decacationic Pillar[5]arene: A New Scaffold for the Development of Xe MRI Imaging Agents.
作者信息
Fernando P U Ashvin I, Shepelytskyi Yurii, Cesana Paul T, Wade Alanna, Grynko Vira, Mendieta Adriana M, Seveney Lauren E, Brown Joseph D, Hane Francis T, Albert Mitchell S, DeBoef Brenton
机构信息
Department of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island 02881, United States.
U.S. Army Corps of Engineers, Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, Mississippi 39180, United States.
出版信息
ACS Omega. 2020 Oct 20;5(43):27783-27788. doi: 10.1021/acsomega.0c02565. eCollection 2020 Nov 3.
A decacationic water-soluble pillar[5]arene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-based studies also demonstrate that xenon binds into the cavity of the pillararene with an association constant of 4.6 × 10 M. These data indicate that the water-soluble pillararene is a potential scaffold for building contrast agents that can be detected by xenon-129 magnetic resonance imaging.
一种具有非溶剂化疏水核心的十阳离子水溶性柱[5]芳烃已被设计并合成。这种超分子主体能够结合氙，超CEST耗竭实验证明了这一点。基于荧光的研究还表明，氙以4.6×10 M的缔合常数结合到柱芳烃的空腔中。这些数据表明，水溶性柱芳烃是构建可通过氙-129磁共振成像检测的造影剂的潜在支架。
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