酵母核糖核苷酸还原酶小亚基基因的鉴定及其对甲磺酸甲酯的诱导性
Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate.
作者信息
Hurd H K, Roberts C W, Roberts J W
机构信息
Section of Biochemistry, Molecular & Cell Biology, Cornell University, Ithaca, New York 14853.
出版信息
Mol Cell Biol. 1987 Oct;7(10):3673-7. doi: 10.1128/mcb.7.10.3673-3677.1987.
Abstract
We have identified, cloned, and sequenced the gene for the small subunit of ribonucleotide diphosphate reductase of Saccharomyces cerevisiae. The protein and its transcript are induced about 10-fold by the alkylating agent methyl methanesulfonate, a result which suggests that the gene is induced by DNA damage.
摘要
我们已经鉴定、克隆并测序了酿酒酵母核糖核苷酸二磷酸还原酶小亚基的基因。该蛋白及其转录本被烷基化剂甲磺酸甲酯诱导了约10倍，这一结果表明该基因是由DNA损伤诱导的。
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