Department of Pathology, Oregon Health & Science University, L-471, Portland, OR 97239, USA.
Department of Laboratories, Seattle Children's Hospital, OC.8.720, Seattle, WA 98105, USA.
Surg Pathol Clin. 2020 Dec;13(4):739-762. doi: 10.1016/j.path.2020.08.009.
Pediatric fibroblastic/myofibroblastic tumors are rare but include a wide variety of benign to malignant tumors. Given their uncommon frequency, they may present as a diagnostic dilemma. This article is focused on using clinical and pathologic clues in conjunction with the increasingly relevant and available molecular techniques to classify, predict prognosis, and/or guide treatment in these tumors.
儿科纤维母细胞/肌纤维母细胞瘤较为罕见,但包含多种良性至恶性肿瘤。由于其罕见的发病率,它们可能表现为诊断难题。本文主要关注利用临床和病理线索,结合日益相关和可用的分子技术,对这些肿瘤进行分类、预测预后和/或指导治疗。