长期 COVID-19 相关嗅觉丧失的嗅上皮组织病理学发现。
Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia.
机构信息
Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Italy.
Biomedical Science Department, University of Sassari, Italy.
出版信息
J Laryngol Otol. 2020 Dec;134(12):1123-1127. doi: 10.1017/S0022215120002455. Epub 2020 Nov 16.
BACKGROUND
Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated.
CASE REPORT
This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2.
CONCLUSION
The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.
背景
嗅觉功能障碍是 2019 冠状病毒病（COVID-19）最常见的症状之一，约影响 70%的患者。然而，COVID-19 患者嗅觉功能障碍的发病机制尚未阐明。
病例报告
本报告介绍了一名患者的放射学和组织病理学发现，该患者在感染严重急性呼吸综合征冠状病毒 2 后，持续超过三个月出现嗅觉丧失。
结论
活检显示嗅觉上皮显著破坏。这将焦点从嗅球的侵犯转移开来，并鼓励进一步研究针对表面上皮的治疗方法。
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