Department of Psychiatry, University of Melbourne and St Vincent's Hospital.
Centre for Mental Health, Swinburne University, Melbourne, Australia.
Int Clin Psychopharmacol. 2021 Mar 1;36(2):61-75. doi: 10.1097/YIC.0000000000000342.
Body dysmorphic disorder (BDD) is characterized by a preoccupation with a perceived appearance flaw or flaws that are not observable to others. BDD is associated with distress and impairment of functioning. Psychiatric comorbidities, including depression, social anxiety, and obsessive-compulsive disorder are common and impact treatment. Treatment should encompass psychoeducation, particularly addressing the dangers associated with cosmetic procedures, and may require high doses of selective serotonin reuptake inhibitors* (SSRI*) and protracted periods to establish full benefit. If there is an inadequate response to SSRIs, various adjunctive medications can be employed including atypical antipsychotics*, anxiolytics*, and the anticonvulsant levetiracetam*. However, large-scale randomized controlled trials are lacking and BDD is not an approved indication for these medications. Oxytocin* may have a potential role in treating BDD, but this requires further exploration. Cognitive-behavioural therapy has good evidence for efficacy for BDD, and on-line and telephone-assisted forms of therapy are showing promise. CBT for BDD should be customized to address such issues as mirror use, perturbations of gaze, and misinterpretation of others' emotions, as well as overvalued ideas about how others view the individual.
躯体变形障碍(BDD)的特征是对他人无法观察到的感知到的外貌缺陷或缺陷的过分关注。BDD 与痛苦和功能障碍有关。常见的精神病共病包括抑郁、社交焦虑和强迫症,这些共病会影响治疗。治疗应包括心理教育,特别是要解决与美容手术相关的危险,可能需要高剂量的选择性 5-羟色胺再摄取抑制剂(SSRI*)和长时间才能获得全部益处。如果对 SSRI 反应不足,可以使用各种辅助药物,包括非典型抗精神病药*、抗焦虑药和抗惊厥药左乙拉西坦。然而,缺乏大规模的随机对照试验,BDD 也不是这些药物的批准适应证。催产素*在治疗 BDD 方面可能具有潜在作用,但这需要进一步探索。认知行为疗法对 BDD 的疗效有很好的证据,在线和电话辅助形式的治疗也显示出前景。BDD 的 CBT 应根据具体情况进行调整,以解决诸如照镜子、注视干扰和误解他人情绪以及对他人如何看待个体的过高评价等问题。