Tang Xingxing, Cao Yudong, Liu Jia, Wang Shuo, Yang Yong, Du Peng
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Urology, Peking University Cancer Hospital & Institute, Beijing, China.
Front Mol Biosci. 2020 Nov 5;7:575483. doi: 10.3389/fmolb.2020.575483. eCollection 2020.
We conducted this study to evaluate the diagnostic value of Inflammatory Factors (IFs) in the pathology of bladder cancer patients. The patients who were diagnosed with urothelial bladder carcinoma (bladder cancer) and underwent surgical treatment in our center from 2014 to 2019 were enrolled. The values of Neutrophil to Lymphocyte Ratio (NLR), derived Neutrophil to Lymphocyte Ratio (dNLR), Platelet to Lymphocyte Ratio (PLR), Lymphocyte to Monocyte Ratio (LMR), Systemic Immune-inflammation Index (SII), and Prognostic Nutritional Index (PNI) were calculated by blood routine test results before operation. After obtaining the postoperative pathology of the patients, the Area Under Curve (AUC) of Receiver Operating Characteristic (ROC) curves was calculated to evaluate the diagnostic value of these IFs in pathology and their corresponding cut-off values. A total of 641 bladder cancer patients were enrolled. The median values of NLR, dNLR, PLR, LMR, SII, and PNI were 6.33, 4.09, 156.47, 2.66, 1114.29, and 51.45, respectively. Grouped patients according to the pathological grade, the NLR, dNLR, PLR, and SII of the high-grade group were significantly higher than those of the low-grade group ( < 0.001, < 0.001, < 0.001, and < 0.001, respectively), while the LMR and PNI were significantly lower than those of the low-grade group ( = 0.003 and < 0.001). Divided patients into non-muscle invasion group (Tis + Ta + T1) and muscle invasion group (T2 + T3 + T4), in which NLR, dNLR, PLR, and SII in the muscle invasion group were significantly higher than those in the non-muscle invasion group ( < 0.001, < 0.001, < 0.001, and < 0.001, respectively), while LMR and PNI were significantly lower than those in the low-grade group ( = 0.012 and < 0.001). ROC curves analyses showed that NLR, dNLR, PLR, LMR, SII, and PNI had predictive value for pathological grade ( < 0.001, < 0.001, < 0.001, < 0.001, < 0.001, < 0.001, and < 0.001, respectively) and muscle invasion ( < 0.001, < 0.001, < 0.001, < 0.001, < 0.001, < 0.001, and < 0.001, respectively). The results suggest the higher NLR, dNLR, PLR, SII, and lower LMR and PNI are associated with higher risk of high-grade and muscle invasive disease. However, this conclusion needs to be further clarified in the future.
我们开展这项研究以评估炎症因子（IFs）在膀胱癌患者病理诊断中的价值。纳入了2014年至2019年期间在本中心被诊断为尿路上皮膀胱癌（膀胱癌）并接受手术治疗的患者。术前通过血常规检测结果计算中性粒细胞与淋巴细胞比值（NLR）、衍生中性粒细胞与淋巴细胞比值（dNLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）、全身免疫炎症指数（SII）和预后营养指数（PNI）的值。获取患者术后病理结果后，计算受试者工作特征（ROC）曲线的曲线下面积（AUC），以评估这些炎症因子在病理诊断中的价值及其相应的临界值。共纳入641例膀胱癌患者。NLR、dNLR、PLR、LMR、SII和PNI的中位数分别为6.33、4.09、156.47、2.66、1114.29和51.45。根据病理分级对患者进行分组，高级别组的NLR、dNLR、PLR和SII显著高于低级别组（分别为P<0.001、P<0.001、P<0.001和P<0.001），而LMR和PNI显著低于低级别组（P = 0.003和P<0.001）。将患者分为非肌层浸润组（Tis + Ta + T1）和肌层浸润组（T2 + T3 + T4），其中肌层浸润组的NLR、dNLR、PLR和SII显著高于非肌层浸润组（分别为P<0.001、P<0.001、P<0.001和P<0.
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