体温与新陈代谢的昼夜节律。
Circadian rhythmicity of body temperature and metabolism.
作者信息
Refinetti Roberto
机构信息
Department of Psychology, University of New Orleans, New Orleans, LA, USA.
出版信息
Temperature (Austin). 2020 Apr 17;7(4):321-362. doi: 10.1080/23328940.2020.1743605. eCollection 2020.
This article reviews the literature on the circadian rhythms of body temperature and whole-organism metabolism. The two rhythms are first described separately, each description preceded by a review of research methods. Both rhythms are generated endogenously but can be affected by exogenous factors. The relationship between the two rhythms is discussed next. In endothermic animals, modulation of metabolic activity can affect body temperature, but the rhythm of body temperature is not a mere side effect of the rhythm of metabolic thermogenesis associated with general activity. The circadian system modulates metabolic heat production to generate the body temperature rhythm, which challenges homeothermy but does not abolish it. Individual cells do not regulate their own temperature, but the relationship between circadian rhythms and metabolism at the cellular level is also discussed. Metabolism is both an output of and an input to the circadian clock, meaning that circadian rhythmicity and metabolism are intertwined in the cell.
本文综述了有关体温和机体整体代谢昼夜节律的文献。首先分别描述这两种节律，每种描述之前先回顾研究方法。这两种节律均由内源性产生，但可受外源性因素影响。接下来讨论这两种节律之间的关系。在恒温动物中，代谢活动的调节可影响体温，但体温节律并非与一般活动相关的代谢产热节律的单纯副作用。昼夜节律系统调节代谢产热以产生体温节律，这对体温恒定提出了挑战，但并未将其消除。单个细胞并不调节自身温度，但也讨论了细胞水平上昼夜节律与代谢之间的关系。代谢既是生物钟的输出，也是其输入，这意味着昼夜节律性与代谢在细胞中相互交织。
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