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精神分裂症患者颞叶的结构与功能改变:文献综述

Structural and Functional Alterations of the Temporal lobe in Schizophrenia: A Literature Review.

作者信息

Kaur Arveen, Basavanagowda Deepak M, Rathod Bindu, Mishra Nupur, Fuad Sehrish, Nosher Sadia, Alrashid Zaid A, Mohan Devyani, Heindl Stacey E

机构信息

Psychiatry and Behavioral Sciences, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

出版信息

Cureus. 2020 Oct 26;12(10):e11177. doi: 10.7759/cureus.11177.

Abstract

Schizophrenia is a severe chronic mental illness leading to social and occupational dysfunction. Our primary focus in this review article was to analyze further the structural and functional alterations of the temporal lobe in patients with schizophrenia, which might contribute to the associated manifestations we often see in this illness. Our goal was to see if there was any correlation between temporal lobe abnormalities, more specifically, alterations in brain volume and specific symptoms such as auditory and language processing, etc. There is a positive correlation between volume alterations and thoughts disorders in the temporal lobe in the majority of studies. However, superior temporal gyrus volume has also been correlated negatively with the severity of hallucinations and thought disorders in some studies. We utilized Medical Subject Heading (MeSH) search strategy via PubMed database in our articles search yielding 241 papers. After the application of specific inclusion and exclusion criteria, a final number of 30 was reviewed. The involvement of the temporal lobe and its gray and white matter volume alterations in schizophrenia is quite apparent from our research; however, the exact mechanism of the underlying biological process is not thoroughly studied yet. Therefore, further research on larger cohorts combining different imaging modalities including volumetry, diffusion tensor, and functional imaging is required to explain how the progressive brain changes affect the various structural, functional, and metabolic activities of the temporal lobe in schizophrenia.

摘要

精神分裂症是一种导致社会和职业功能障碍的严重慢性精神疾病。在这篇综述文章中,我们的主要重点是进一步分析精神分裂症患者颞叶的结构和功能改变,这些改变可能导致我们在该疾病中经常看到的相关表现。我们的目标是查看颞叶异常之间是否存在任何相关性,更具体地说,脑容量改变与诸如听觉和语言处理等特定症状之间是否存在相关性。在大多数研究中,颞叶的容量改变与思维障碍之间存在正相关。然而,在一些研究中,颞上回体积也与幻觉和思维障碍的严重程度呈负相关。我们在文章检索中通过PubMed数据库采用医学主题词(MeSH)检索策略,共检索到241篇论文。应用特定的纳入和排除标准后,最终审查了30篇论文。从我们的研究中可以明显看出,颞叶及其灰质和白质体积改变在精神分裂症中的作用;然而,潜在生物学过程的确切机制尚未得到充分研究。因此,需要对更大的队列进行进一步研究,结合包括容积测量、扩散张量和功能成像在内的不同成像方式,以解释渐进性脑变化如何影响精神分裂症患者颞叶的各种结构、功能和代谢活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1f/7689947/b79dfc88bf0c/cureus-0012-00000011177-i01.jpg

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