[Prevention of nephrolithiasis - Preliminary results of the Swiss Kidney Stone Cohort (SKSC) and the NOSTONE trial].

Nephrolithiasis is a major health care problem with increasing incidence and prevalence worldwide. Prevention consists mainly of conservative therapeutic measures, including dietary measures and drug treatments. However, the understanding of the pathophysiology and molecular genetic basis of nephrolithiasis is incomplete and complicates the development of new treatments. In this context, the Swiss Kidney Stone Cohort (SKSC) aims to improve the understanding of nephrolithiasis and the NOSTONE trial aims to confirm the efficacy of hydrochlorothiazide in the recurrence prevention of calcium containing kidney stones.