Cornea and External Diseases Department, Massachusetts Eye and Ear Infirmary, Harvard Ophthalmology, Boston, MA.
Cornea. 2021 Jan;40(1):116-120. doi: 10.1097/ICO.0000000000002421.
To describe 3 cases of corneal clearance after the use of topical rho-kinase inhibitor, netarsudil, in the setting of endothelial cell dysfunction in comparison to one case without corneal clearance after the use of netarsudil.
Four patients presenting to a busy academic clinical corneal practice with visual complaints from corneal edema secondary to endothelial cell dysfunction were treated with topical netarsudil one drop daily in the affected eye.
Corneal clearance was observed in 1) a case of peripheral corneal edema in the setting of iridocorneal endothelial syndrome after 4 weeks on netarsudil, 2) a case of corneal edema in the setting of early penetrating keratoplasty graft failure after 2-week use of netarsudil, and 3) a case of corneal edema in the setting of chronic penetrating keratoplasty graft failure after 4-week use of netarsudil. Corneal clearance was not observed in a case of corneal edema in the setting of pseudophakic bullous keratopathy from previous complicated intraocular lens exchange surgery with placement of an anterior chamber intraocular lens after the use of netarsudil for 12 weeks.
Addition of topical rho-kinase inhibitor in the form of netarsudil can result in corneal clearance in a variety of certain cases of endothelial cell dysfunction, not previously documented in the literature.
描述 3 例在 Rho 激酶抑制剂（他氟前列素）治疗内皮细胞功能障碍导致角膜水肿患者中观察到的角膜水肿消退的病例，并与 1 例未观察到角膜水肿消退的病例进行比较。
4 例因内皮细胞功能障碍导致角膜水肿而出现视觉问题的患者在受累眼每日接受他氟前列素滴眼治疗。
1）在虹膜角膜内皮综合征的周边角膜水肿患者中，在使用他氟前列素 4 周后观察到角膜水肿消退；2）在穿透性角膜移植失败 2 周后使用他氟前列素治疗的患者中，观察到角膜水肿消退；3）在慢性穿透性角膜移植失败患者中，使用他氟前列素 4 周后观察到角膜水肿消退。然而，在先前复杂的人工晶状体置换手术后出现假性晶状体囊膜下混浊性角膜水肿的患者中，在使用他氟前列素 12 周后并未观察到角膜水肿消退，尽管在该患者中使用了前房人工晶状体。
在 Rho 激酶抑制剂（他氟前列素）治疗内皮细胞功能障碍的多种情况下，可观察到角膜水肿消退，这在文献中尚未有报道。
