PAKC：一种新型的 HLA I 类抗原呈递机制敲除细胞面板，源自同一遗传起源。
PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin.
机构信息
Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.
Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
出版信息
Eur J Immunol. 2021 Mar;51(3):734-737. doi: 10.1002/eji.202048599. Epub 2021 Feb 1.
Abstract
A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity.
摘要
目前缺乏一个整合抗原呈递多个方面的单一模型系统。PAKC 是一个由十个细胞系组成的新型面板，这些细胞系敲除了 HLA Ⅰ类抗原呈递途径的单个成分。PAKC 将加速肿瘤学、传染病学和自身免疫学等领域的 HLA-I 研究。
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