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通过实时质谱直接分析进行天然产物发现

Natural Product Discovery by Direct Analysis in Real Time Mass Spectrometry.

作者信息

Yew Joanne Y

机构信息

Pacific Biosciences Research Center, University of Hawai'i at Mānoa, 1993 East West Road, Honolulu, HI 96822, USA.

出版信息

Mass Spectrom (Tokyo). 2019;8(2):S0081. doi: 10.5702/massspectrometry.S0081. Epub 2020 Jan 11.

DOI:10.5702/massspectrometry.S0081
PMID:33299731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7709883/
Abstract

Direct analysis in real time mass spectrometry (DART MS) is one of the first ambient ionization methods to be introduced and commercialized. Analysis by DART MS requires minimal sample preparation, produces nearly instantaneous results, and provides detection over a broad range of compounds. These advantageous features are particularly well-suited for the inherent complexity of natural product analysis. This review highlights recent applications of DART MS for species identification by chemotaxonomy, chemical profiling, genetic screening, and chemical spatial analysis from plants, insects, microbes, and metabolites from living systems.

摘要

实时直接分析质谱法（DART MS）是最早被引入并商业化的常压电离方法之一。采用DART MS进行分析所需的样品制备极少，能产生近乎即时的结果，并可对多种化合物进行检测。这些优势特性特别适合天然产物分析固有的复杂性。本综述重点介绍了DART MS最近在植物、昆虫、微生物以及生物系统代谢产物的化学分类学物种鉴定、化学轮廓分析、基因筛选和化学空间分析中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded8/7709883/9bdd9414959d/massspectrometry-8-2-S0081-figure03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded8/7709883/7d2088075db9/massspectrometry-8-2-S0081-figure01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded8/7709883/73e7b24b33ab/massspectrometry-8-2-S0081-figure02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded8/7709883/9bdd9414959d/massspectrometry-8-2-S0081-figure03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded8/7709883/7d2088075db9/massspectrometry-8-2-S0081-figure01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded8/7709883/73e7b24b33ab/massspectrometry-8-2-S0081-figure02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded8/7709883/9bdd9414959d/massspectrometry-8-2-S0081-figure03.jpg

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Carbon-carbon double bond position elucidation in fatty acids using ozone-coupled direct analysis in real time mass spectrometry.利用臭氧偶联实时直接分析质谱法阐明脂肪酸中的碳-碳双键位置。
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Detection of very long-chain hydrocarbons by laser mass spectrometry reveals novel species-, sex-, and age-dependent differences in the cuticular profiles of three Nasonia species.
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Direct Analysis in Real Time-Mass Spectrometry and Kohonen Artificial Neural Networks for Species Identification of Larva, Pupa and Adult Life Stages of Carrion Insects.实时直接分析-质谱法和科恩神经网络在腐肉昆虫幼虫、蛹和成虫生活阶段的物种鉴定中的应用。
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