Long-term oncological outcomes of the Agarwal loop-ligation technique for management of the distal ureter during laparoscopic radical nephroureterectomy.

作者信息

Hoe Venetia, Yao Henry H, Crozier Jack, Kanagarajah Abbie, Florescu Grace, Kearsley Jamie, Dundee Philip, O'Connell Helen E, Lawrentschuk Nathan, Agarwal Dinesh K

机构信息

Department of Urology, Western Health, Melbourne, Vic., Australia.

University of Melbourne, Parkville, Vic., Australia.

出版信息

BJU Int. 2021 Jul;128(1):112-121. doi: 10.1111/bju.15321. Epub 2021 Jan 5.

OBJECTIVES

To describe the Agarwal loop-ligation technique for the management of the distal ureter during laparoscopic radical nephroureterectomy (LRNU) for upper tract urothelial carcinoma (UTUC) and report on long-term oncological outcomes.

PATIENTS AND METHODS

In the Agarwal loop-ligation technique, the distal ureteric stump is controlled using endoscopic Endoloop or PolyLoop ligation to ensure en bloc excision of the bladder cuff and prevent spillage of upper tract urine into the perivesical space. A retrospective review of the medical records of 76 patients who underwent the Agarwal loop-ligation technique for UTUC at participating centres from July 2004 to December 2017 was performed. Data collected included demographics, perioperative, and long-term oncological outcomes. Survival was calculated using Kaplan-Meier survival analyses.

RESULTS AND LIMITATIONS

A total of 76 patients were included. The median age was 71.5 years and median operative time was 4.3 h. The intramural ureter and bladder cuff were completely excised in all patients. Distal surgical margins were clear in all, with only two patients found to have tumour extending to the circumferential surgical margin. There were no cases of perivesical recurrence or port-site metastasis. The 5-year bladder, local, and contralateral recurrence-free survival was 59.6%, 89.0% and 93.5%, respectively. Metastasis-free survival at 5-years was 73.5%. The 5-year overall survival and cancer-specific survival rates were 70.3% and 84.7%, respectively.

CONCLUSIONS

We have described the Agarwal loop-ligation technique for the management of the distal ureter in LRNU. This technique complies with oncological principles outlined in the European Association of Urology guidelines, which minimises tumour spillage. Long-term oncological outcomes are satisfactory, with no cases of perivesical recurrence detected in this series.